Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases

Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases

Abstract The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence of metastatic brain tumors, it is a challe...

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Published in:Neuro-oncology advances Vol. 3; no. Supplement_5; pp. v133 - v143
Main Authors: Blethen, Kathryn E, Arsiwala, Tasneem A, Fladeland, Ross A, Sprowls, Samuel A, Panchal, Dhruvi M, Adkins, Chris E, Kielkowski, Brooke N, Earp, Leland E, Glass, Morgan J, Pritt, Trenton A, Cabuyao, Yssabela M, Aulakh, Sonikpreet, Lockman, Paul R
Format: Journal Article
Language:English
Published: US Oxford University Press 01-11-2021
Subjects:
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blood-brain barrier
breast cancer
drug delivery
brain metastases
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Abstract Abstract The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence of metastatic brain tumors, it is a challenge for drug delivery. Although the blood-tumor barrier is slightly leaky, it still is not permissive enough to allow the accumulation of therapeutic drug concentrations in brain metastases. Herein, we discuss the differences between primary brain tumors and metastatic brain tumors vasculature, effects of therapeutics on the blood-tumor barrier, and characteristics to be manipulated for more effective drug delivery.
AbstractList Abstract The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence of metastatic brain tumors, it is a challenge for drug delivery. Although the blood-tumor barrier is slightly leaky, it still is not permissive enough to allow the accumulation of therapeutic drug concentrations in brain metastases. Herein, we discuss the differences between primary brain tumors and metastatic brain tumors vasculature, effects of therapeutics on the blood-tumor barrier, and characteristics to be manipulated for more effective drug delivery.
The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence of metastatic brain tumors, it is a challenge for drug delivery. Although the blood-tumor barrier is slightly leaky, it still is not permissive enough to allow the accumulation of therapeutic drug concentrations in brain metastases. Herein, we discuss the differences between primary brain tumors and metastatic brain tumors vasculature, effects of therapeutics on the blood-tumor barrier, and characteristics to be manipulated for more effective drug delivery.
Author Glass, Morgan J
Panchal, Dhruvi M
Pritt, Trenton A
Fladeland, Ross A
Blethen, Kathryn E
Arsiwala, Tasneem A
Sprowls, Samuel A
Adkins, Chris E
Cabuyao, Yssabela M
Kielkowski, Brooke N
Lockman, Paul R
Earp, Leland E
Aulakh, Sonikpreet
AuthorAffiliation 2 Department of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University , Morgantown, West Virginia , USA
4 Department of Pharmaceutical Sciences, School of Pharmacy, South University , Savannah, Georgia , USA
3 Department of Cancer Cell Biology, School of Medicine, West Virginia University , Morgantown, West Virginia , USA
1 Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University , Morgantown, West Virginia , USA
AuthorAffiliation_xml – name: 3 Department of Cancer Cell Biology, School of Medicine, West Virginia University , Morgantown, West Virginia , USA
– name: 1 Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University , Morgantown, West Virginia , USA
– name: 2 Department of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University , Morgantown, West Virginia , USA
– name: 4 Department of Pharmaceutical Sciences, School of Pharmacy, South University , Savannah, Georgia , USA
Author_xml – sequence: 1
  givenname: Kathryn E
  orcidid: 0000-0003-4602-9514
  surname: Blethen
  fullname: Blethen, Kathryn E
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
– sequence: 2
  givenname: Tasneem A
  surname: Arsiwala
  fullname: Arsiwala, Tasneem A
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
– sequence: 3
  givenname: Ross A
  surname: Fladeland
  fullname: Fladeland, Ross A
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
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  givenname: Samuel A
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  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
– sequence: 5
  givenname: Dhruvi M
  surname: Panchal
  fullname: Panchal, Dhruvi M
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
– sequence: 6
  givenname: Chris E
  surname: Adkins
  fullname: Adkins, Chris E
  organization: Department of Pharmaceutical Sciences, School of Pharmacy, South University, Savannah, Georgia, USA
– sequence: 7
  givenname: Brooke N
  surname: Kielkowski
  fullname: Kielkowski, Brooke N
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
– sequence: 8
  givenname: Leland E
  surname: Earp
  fullname: Earp, Leland E
  organization: Department of Cancer Cell Biology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA
– sequence: 9
  givenname: Morgan J
  surname: Glass
  fullname: Glass, Morgan J
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
– sequence: 10
  givenname: Trenton A
  surname: Pritt
  fullname: Pritt, Trenton A
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
– sequence: 11
  givenname: Yssabela M
  surname: Cabuyao
  fullname: Cabuyao, Yssabela M
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
– sequence: 12
  givenname: Sonikpreet
  surname: Aulakh
  fullname: Aulakh, Sonikpreet
  organization: Department of Cancer Cell Biology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA
– sequence: 13
  givenname: Paul R
  surname: Lockman
  fullname: Lockman, Paul R
  email: prlockman@hsc.wvu.edu
  organization: Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA
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Issue Supplement_5
Keywords blood-brain barrier
breast cancer
drug delivery
brain metastases
Language English
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Snippet Abstract The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low...
The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is...
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Title Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases
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https://pubmed.ncbi.nlm.nih.gov/PMC8633736
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