Rate of abnormalities in quantitative MR neuroimaging of persons with chronic traumatic brain injury

• Published in: BMC neurology Vol. 24; no. 1; pp. 235 - 13
• Main Authors: Rahmani, Farzaneh, Batson, Richard D, Zimmerman, Alexandra, Reddigari, Samir, Bigler, Erin D, Lanning, Shawn C, Ilasa, Eveline, Grafman, Jordan H, Lu, Hanzhang, Lin, Alexander P, Raji, Cyrus A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05-07-2024; BioMed Central; BMC
• Subjects: Abnormalities; Adult; Asymmetry; Atrophy; Atrophy - pathology; Blood flow; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain - pathology; Brain Injuries, Traumatic - diagnostic imaging; Brain Injuries, Traumatic - metabolism; Brain Injuries, Traumatic - pathology; Cerebellum; Cerebral blood flow; Cerebrovascular Circulation - physiology; Complications; Diffusion Tensor Imaging; Diffusion Tensor Imaging - methods; Female; Heart; Humans; Image processing; Injuries; Lateral diffusion; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic resonance spectroscopy; Magnetic Resonance Spectroscopy - methods; Male; Medical imaging; Metabolites; Methods; Middle Aged; N-Acetylaspartate; Neuroimaging; Neuroimaging - methods; Neurological research; Perfusion; Post traumatic stress disorder; Pseudocontinuous arterial spin labeling; Sensitivity analysis; Software; Spectrum analysis; Spin labeling; Standard scores; Substantia alba; Substantia grisea; Trauma; Traumatic brain Injury; United States; United States > US; Magnetic resonance spectroscopy; Pseudocontinuous arterial spin labeling; Traumatic brain Injury; Diffusion Tensor Imaging
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-024-03745-6

Mild traumatic brain injury (mTBI) can result in lasting brain damage that is often too subtle to detect by qualitative visual inspection on conventional MR imaging. Although a number of FDA-cleared MR neuroimaging tools have demonstrated changes associated with mTBI, they are still under-utilized in clinical practice.
We investigated a group of 65 individuals with predominantly mTBI (60 mTBI, 48 due to motor-vehicle collision, mean age 47 ± 13 years, 27 men and 38 women) with MR neuroimaging performed in a median of 37 months post-injury. We evaluated abnormalities in brain volumetry including analysis of left-right asymmetry by quantitative volumetric analysis, cerebral perfusion by pseudo-continuous arterial spin labeling (PCASL), white matter microstructure by diffusion tensor imaging (DTI), and neurometabolites via magnetic resonance spectroscopy (MRS).
All participants demonstrated atrophy in at least one lobar structure or increased lateral ventricular volume. The globus pallidi and cerebellar grey matter were most likely to demonstrate atrophy and asymmetry. Perfusion imaging revealed significant reductions of cerebral blood flow in both occipital and right frontoparietal regions. Diffusion abnormalities were relatively less common though a subset analysis of participants with higher resolution DTI demonstrated additional abnormalities. All participants showed abnormal levels on at least one brain metabolite, most commonly in choline and N-acetylaspartate.
We demonstrate the presence of coup-contrecoup perfusion injury patterns, widespread atrophy, regional brain volume asymmetry, and metabolic aberrations as sensitive markers of chronic mTBI sequelae. Our findings expand the historic focus on quantitative imaging of mTBI with DTI by highlighting the complementary importance of volumetry, arterial spin labeling perfusion and magnetic resonance spectroscopy neurometabolite analyses in the evaluation of chronic mTBI.