Affinity and kinetic modulation of polyamide-DNA interactions by N-modification of the heterocycles

Synthetic N‐methyl imidazole and N‐pyrrole containing polyamides (PAs) that can form “stacked” dimers can be programmed to target and bind to specific DNA sequences and control gene expression. To accomplish this goal, the development of PAs with lower molecular mass which allows for the molecules t...

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Bibliographic Details
Published in:	Biopolymers Vol. 99; no. 8; pp. 497 - 507
Main Authors:	Ramos, Joseph P., Babu, Balaji, Chavda, Sameer, Liu, Yang, Plaunt, Adam, Ferguson, Amanda, Savagian, Mia, Lee, Megan, Tzou, Samuel, Lin, Shicai, Kiakos, Konstantinos, Wang, Shuo, Lee, Moses, Hartley, John A., Wilson, W. David
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-08-2013
Subjects:	ACGCGT Base Sequence binding affinity cell-cycle box Circular Dichroism diamino dicationic DNA DNA - chemistry gene control imidazole kinetics MCB minor groove binder Mlu1 Nylons polyamides pyrrole sequence selectivity Surface Plasmon Resonance
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