Functionalized magnetic nanoparticles as vehicles for the delivery of the antitumor drug gemcitabine to tumor cells. Physicochemical in vitro evaluation

Gemcitabine is a chemotherapy drug used in different carcinomas, although because it displays a short biological half-life, its plasmatic levels can quickly drop below the effective threshold. Nanoparticle-based drug delivery systems can provide an alternative approach for regulating the bioavailabi...

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Bibliographic Details
Published in:	Materials Science & Engineering C Vol. 33; no. 3; pp. 1183 - 1192
Main Authors:	Viota, J.L., Carazo, A., Munoz-Gamez, J.A., Rudzka, K., Gómez-Sotomayor, R., Ruiz-Extremera, A., Salmerón, J., Delgado, A.V.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-04-2013
Subjects:	Acrylic Resins - chemistry Adsorption Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects Chemical Phenomena Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxycytidine - therapeutic use Drug Delivery Systems Electrophoresis Electrophoretic mobility Folic Acid - analysis Gemcitabine Humans Hydrogen-Ion Concentration - drug effects Magnetic nanoparticles Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - ultrastructure Microscopy, Confocal Neoplasms - drug therapy Optical Imaging Particle Size Polyelectrolyte coating Soft particle Tumor cell Polyelectrolyte coating Gemcitabine Electrophoretic mobility Soft particle Tumor cell Magnetic nanoparticles
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