Quinine loading dose in cerebral malaria

In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) pro...

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Bibliographic Details
Published in:	The American journal of tropical medicine and hygiene Vol. 32; no. 1; p. 1
Main Authors:	White, N J, Looareesuwan, S, Warrell, D A, Warrell, M J, Chanthavanich, P, Bunnag, D, Harinasuta, T
Format:	Journal Article
Language:	English
Published:	United States 01-01-1983
Subjects:	Adolescent Adult Brain Diseases - drug therapy Female Humans Infusions, Parenteral Malaria - drug therapy Male Mathematics Plasmodium falciparum Quinine - administration & dosage Quinine - adverse effects Quinine - blood
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Summary:	In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.
ISSN:	0002-9637
DOI:	10.4269/ajtmh.1983.32.1