The development and structure of the HEALthy Brain and Child Development (HBCD) Study EEG protocol

• Published in: Developmental cognitive neuroscience Vol. 69; p. 101447
• Main Authors: Fox, Nathan A., Pérez-Edgar, Koraly, Morales, Santiago, Brito, Natalie H., Campbell, Alana M., Cavanagh, James F., Gabard-Durnam, Laurel Joy, Hudac, Caitlin M., Key, Alexandra P., Larson-Prior, Linda J., Pedapati, Ernest V., Norton, Elizabeth S., Reetzke, Rachel, Roberts, Timothy P., Rutter, Tara M., Scott, Lisa S., Shuffrey, Lauren C., Antúnez, Martín, Boylan, Maeve R., Garner, Bailey M., Learnard, Britley, McNair, Savannah, McSweeney, Marco, Castillo, Maria Isabella Natale, Norris, Jessica, Nyabingi, Olufemi Shakuur, Pini, Nicolò, Quinn, Alena, Stosur, Rachel, Tan, Enda, Troller-Renfree, Sonya V., Yoder, Lydia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-10-2024; Elsevier
• Subjects: Auditory oddball; EEG; Face processing; HBCD; Infants; Longitudinal cohort; Original Research; Protocols; Resting EEG; Visual evoked potentials; Protocols; EEG; Visual evoked potentials; HBCD; Infants; Longitudinal cohort; Resting EEG; Auditory oddball; Face processing
• ISSN: 1878-9293; 1878-9307; 1878-9307
• DOI: 10.1016/j.dcn.2024.101447

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Electroencephalography (EEG) is one of two brain imaging modalities central to the HBCD Study. EEG records electrical signals from the scalp that reflect electrical brain activity. In addition, the EEG signal can be synchronized to the presentation of discrete stimuli (auditory or visual) to measure specific cognitive processes with excellent temporal precision (e.g., event-related potentials; ERPs). EEG is particularly helpful for the HBCD Study as it can be used with awake, alert infants, and can be acquired continuously across development. The current paper reviews the HBCD Study’s EEG/ERP protocol: (a) the selection and development of the tasks (Video Resting State, Visual Evoked Potential, Auditory Oddball, Face Processing); (b) the implementation of common cross-site acquisition parameters and hardware, site setup, training, and initial piloting; (c) the development of the preprocessing pipelines and creation of derivatives; and (d) the incorporation of equity and inclusion considerations. The paper also provides an overview of the functioning of the EEG Workgroup and the input from members across all steps of protocol development and piloting.
•The HEALthy Brain and Child Development (HBCD) Study is a multi-site longitudinal study.•This paper outlines the role of EEG in the study and the development of the EEG protocol.•Tasks selected: Video Resting State, Visual Evoked Potential, Auditory Oddball, Face Processing.