Discovery and first-time disclosure of CVN766, an exquisitely selective orexin 1 receptor antagonist

• Published in: Bioorganic & medicinal chemistry letters Vol. 100; p. 129629
• Main Authors: Glen, Angela, Bürli, Roland W., Livermore, David, Buffham, William, Merison, Stephanie, Rowland, Anna E., Newman, Robert, Fieldhouse, Charlotte, Miller, David J., Dawson, Lee A., Matthews, Kim, Carlton, Mark B., Brice, Nicola L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-03-2024
• Subjects: Antagonist; Hypocretin; Orexin; Ox1R; EDC; DIPEA; CHO; HOAT; HATU; Antagonist; Orexin; Hypocretin; Ox1R
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2024.129629

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Modulators of orexin receptors are being developed for neurological illnesses such as sleep disorders, addictive behaviours and other psychiatric diseases. We herein describe the discovery of CVN766, a potent orexin 1 receptor antagonist that has greater than 1000-fold selectivity for the orexin 1 receptor over the orexin 2 receptor and demonstrates low off target hits in a diversity screen. In agreement with its in vitro ADME data, CVN766 demonstrated moderate in vivo clearance in rodents and displayed good brain permeability and target occupancy. This drug candidate is currently being investigated in clinical trials for schizophrenia and related psychiatric conditions.