Clinically established biodegradable long acting injectables: An industry perspective

• Published in: Advanced drug delivery reviews Vol. 167; pp. 19 - 46
• Main Authors: Nkanga, Christian Isalomboto, Fisch, Andreas, Rad-Malekshahi, Mazda, Romic, Marieta Duvnjak, Kittel, Birgit, Ullrich, Thomas, Wang, Jing, Krause, Rui Werner Maçedo, Adler, Sabine, Lammers, Twan, Hennink, Wim E., Ramazani, Farshad
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-12-2020
• Subjects: Drug crystal suspensions; Drug crystals; Drug delivery; Extended release; Implants; In situ forming implants; Long acting injectables; Microspheres; Oil-based formulations; PLGA microparticles; Microspheres; Extended release; PLGA microparticles; Drug crystal suspensions; Long acting injectables; In situ forming implants; Drug crystals; Implants; Oil-based formulations; Drug delivery
• ISSN: 0169-409X; 1872-8294
• DOI: 10.1016/j.addr.2020.11.008

Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorized in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations.
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