The Boltzmann distributions of molecular structures predict likely changes through random mutations

New folded molecular structures can only evolve after arising through mutations. This aspect is modeled using genotype-phenotype maps, which connect sequence changes through mutations to changes in molecular structures. Previous work has shown that the likelihood of appearing through mutations can d...

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Bibliographic Details

Published in:	Biophysical journal Vol. 122; no. 22; pp. 4467 - 4475
Main Authors:	Martin, Nora S, Ahnert, Sebastian E
Format:	Journal Article
Language:	English
Published:	United States The Biophysical Society 21-11-2023
Subjects:	Evolution, Molecular Models, Genetic Molecular Structure Mutation Nucleic Acid Conformation RNA - chemistry
Online Access:	Get full text
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