Handrubbing with sprayed alcohol-based hand rub: an alternative method for effective hand hygiene

• Published in: The Journal of hospital infection Vol. 104; no. 4; pp. 430 - 434
• Main Authors: Tan, J.B.X., de Kraker, M.E.A., Pires, D., Soule, H., Pittet, D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-04-2020
• Subjects: 2-Propanol - administration & dosage; Alcohol-based hand rub; Bacterial Load; EN 1500; Escherichia coli - drug effects; Escherichia coli - isolation & purification; Ethanol; Hand - microbiology; Hand Disinfection - methods; Hand hygiene; Hand Hygiene - methods; Handrubbing; Humans; Spray application; Switzerland; WHO ‘How to handrub’; Switzerland; Alcohol-based hand rub; EN 1500; Handrubbing; WHO ‘How to handrub’; Hand hygiene; Spray application
• ISSN: 0195-6701; 1532-2939
• DOI: 10.1016/j.jhin.2020.02.008

Hand hygiene is crucial in infection prevention and control. It is unclear whether sprayed alcohol-based hand rub (ABHR) is non-inferior to the World Health Organization (WHO)-recommended method of handrubbing with poured ABHR.
To test whether sprayed ABHR can be an alternative (non-inferior) method for effective hand hygiene with/without handrubbing.
A laboratory experiment was conducted with ABHR (isopropanol 60% v/v) according to European Norm 1500. Hand hygiene was performed by: (1) handrubbing with ABHR poured on to the palm of the hand; (2) handrubbing with sprayed ABHR; and (3) applying sprayed ABHR to hands without handrubbing. Hands were contaminated with Escherichia coli ATCC 10536, followed by hand hygiene and microbiological sampling. A generalized linear mixed model with a random intercept per subject was used to analyse the reduction in bacterial count following hand hygiene.
In total, 19 healthcare workers participated in the study. Handrubbing with sprayed ABHR was non-inferior [margin log10 0.6 colony-forming units (cfu)/mL] to the WHO-recommended method of handrubbing with poured ABHR; bacterial count reductions were log10 3.66 cfu/mL [95% confidence interval (CI) 1.68–5.64] and log10 3.46 cfu/mL (95% CI 1.27–5.65), respectively. Conversely, non-inferiority was not found for sprayed ABHR without handrubbing [bacterial count reduction log10 2.76 cfu/mL (95% CI 1.65–3.87)].
Handrubbing with sprayed ABHR was non-inferior to handrubbing with ABHR poured on to the palm of the hand to reduce bacterial counts on hands under experimental conditions. Handrubbing with sprayed ABHR may be an acceptable alternative hand hygiene method pending assessment in other settings and for other pathogens.