Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state

In the development of bio-enabling formulations, innovative in vivo predictive tools to understand and predict the in vivo performance of such formulations are needed. Etravirine, a non-nucleoside reverse transcriptase inhibitor, is currently marketed as an amorphous solid dispersion (Intelence® tab...

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Bibliographic Details

Published in:	European journal of pharmaceutical sciences Vol. 149; p. 105297
Main Authors:	Litou, Chara, Turner, David B., Holmstock, Nico, Ceulemans, Jens, Box, Karl J., Kostewicz, Edmund, Kuentz, Martin, Holm, Rene, Dressman, Jennifer
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-06-2020
Subjects:	Amorphous solid dispersions Bio-enabling formulations Etravirine Modeling and simulation PBPK PBPK Bio-enabling formulations Modeling and simulation Amorphous solid dispersions Etravirine
Online Access:	Get full text
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