Collagen-Induced Arthritis in TNF Receptor-1-Deficient Mice: TNF Receptor-2 Can Modulate Arthritis in the Absence of TNF Receptor-1

TNF is a potent proinflammatory cytokine important for the development of arthritis in human and animals. We have investigated the roles of TNF receptor-1 (TNFR1) and TNF receptor-2 (TNFR2) in collagen-induced arthritis (CIA) by inducing CIA in mice genetically deficient in TNFR1. TNFR1−/− mice deve...

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Bibliographic Details
Published in:	Clinical immunology (Orlando, Fla.) Vol. 99; no. 3; pp. 325 - 333
Main Authors:	Tada, Yoshifumi, Ho, Alexandra, Koarada, Syuichi, Morito, Fumitaka, Ushiyama, Osamu, Suzuki, Noriaki, Kikuchi, Yuji, Ohta, Akihide, Mak, Tak W., Nagasawa, Kohei
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01-06-2001 Elsevier
Subjects:	Animals Antigens, CD - physiology arthritis Arthritis - etiology Arthritis - prevention & control Biological and medical sciences Collagen - immunology Diseases of the osteoarticular system Immunoglobulin G - blood Inflammatory joint diseases Interleukin-1 - biosynthesis Interleukin-6 - biosynthesis Medical sciences Mice Mice, Inbred DBA Receptors, Tumor Necrosis Factor - deficiency Receptors, Tumor Necrosis Factor - physiology Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II TNF TNF receptor tumor necrosis factor receptors Tumor Necrosis Factor-alpha - biosynthesis arthritis TNF TNF receptor Immunopathology Animal model Pathogenesis Cytokine Rodentia Diseases of the osteoarticular system Autoimmune disease Inflammatory joint disease Arthritis Tumor necrosis factor receptor 2 Vertebrata Chronic Mammalia Mouse Tumor necrosis factor Animal Collagen Rheumatoid arthritis Tumor necrosis factor receptor 1 Biological receptor
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