Phosphotyrosine Signaling Networks in Epidermal Growth Factor Receptor Overexpressing Squamous Carcinoma Cells

Overexpression and enhanced activation of the epidermal growth factor (EGF) receptor are frequent events in human cancers that correlate with poor prognosis. Anti-phosphotyrosine and anti-EGFr affinity chromatography, isotope-coded Î¼LC-MS/MS, and immunoblot methods were combined to describe and mea...

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Bibliographic Details
Published in:	Molecular & cellular proteomics Vol. 4; no. 4; pp. 356 - 376
Main Authors:	Thelemann, April, Petti, Filippo, Griffin, Graeme, Iwata, Ken, Hunt, Tony, Settinari, Tina, Fenyo, David, Gibson, Neil, Haley, John D
Format:	Journal Article
Language:	English
Published:	United States American Society for Biochemistry and Molecular Biology 01-04-2005
Subjects:	Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Adhesion Cell Line, Tumor Chromatography, Affinity Chromatography, Liquid Enzyme Activation ErbB Receptors - antagonists & inhibitors ErbB Receptors - drug effects ErbB Receptors - metabolism Erlotinib Hydrochloride Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Immunoblotting Isotopes Mass Spectrometry Models, Biological Peptide Mapping Phosphorylation - drug effects Phosphotyrosine - metabolism Proteins - analysis Quinazolines - pharmacology Signal Transduction - drug effects Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization src-Family Kinases - metabolism
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