Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro

Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition of the synthesis of extracellular matrix (ECM) proteins, as well as an increase in prote...

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Bibliographic Details
Published in:	Nitric oxide Vol. 70; pp. 42 - 50
Main Authors:	Vela-Anero, Á., Hermida-Gómez, T., Gato-Calvo, L., Vaamonde-García, C., Díaz-Prado, S., Meijide-Faílde, R., Blanco, F.J., Burguera, E.F.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2017
Subjects:	Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Catabolism Glycosaminoglycans - analysis Glycosaminoglycans - metabolism Human articular cartilage Humans Hydrogen sulfide Hydrogen Sulfide - pharmacology Immunohistochemistry Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - pharmacology Matrilin Proteins - analysis Matrilin Proteins - metabolism Matrix Metalloproteinase 13 - analysis Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 3 - analysis Matrix Metalloproteinase 3 - metabolism Morpholines - pharmacology Organothiophosphorus Compounds - pharmacology Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism Osteoarthritis - pathology Protective Agents - pharmacology Proteoglycans Sulfides - pharmacology Time Factors Hydrogen sulfide Catabolism Proteoglycans Human articular cartilage Osteoarthritis
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