Synthesis and Biological Activity of Phosphonocarboxylate DNA

Oligodeoxynucleotides containing internucleotide phosphonoacetate esters are taken up irreversibly by cells in culture in the absence of cationic lipids. These oligonucleotides also are active in stimulating RNase H and are stable toward nucleases.

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Published in:	Nucleosides, nucleotides & nucleic acids Vol. 26; no. 6-7; pp. 539 - 546
Main Authors:	Yamada, Christina M., Dellinger, Douglas J., Caruthers, Marvin H.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis Group 01-01-2007
Subjects:	DNA - chemical synthesis DNA - chemistry DNA - metabolism Esterification Flow Cytometry HeLa Cells Humans Jurkat Cells Lipids - chemistry Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Heteroduplexes - metabolism Oligonucleotides - chemistry Oligonucleotides - metabolism passive delivery Phosphonoacetic Acid - analogs & derivatives Phosphonoacetic Acid - chemical synthesis Phosphonoacetic Acid - chemistry Phosphonoacetic Acid - metabolism Phosphonocarboxylate oligonucleotides RNA - chemistry RNA - metabolism Transfection
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Abstract	Oligodeoxynucleotides containing internucleotide phosphonoacetate esters are taken up irreversibly by cells in culture in the absence of cationic lipids. These oligonucleotides also are active in stimulating RNase H and are stable toward nucleases.
AbstractList	Oligodeoxynucleotides containing internucleotide phosphonoacetate esters are taken up irreversibly by cells in culture in the absence of cationic lipids. These oligonucleotides also are active in stimulating RNase H and are stable toward nucleases.
Author	Dellinger, Douglas J. Caruthers, Marvin H. Yamada, Christina M.
Author_xml	– sequence: 1 givenname: Christina M. surname: Yamada fullname: Yamada, Christina M. organization: Department of Chemistry and Biochemistry , University of Colorado – sequence: 2 givenname: Douglas J. surname: Dellinger fullname: Dellinger, Douglas J. organization: Department of Chemistry and Biochemistry , University of Colorado – sequence: 3 givenname: Marvin H. surname: Caruthers fullname: Caruthers, Marvin H. organization: Department of Chemistry and Biochemistry , University of Colorado
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18066852$$D View this record in MEDLINE/PubMed
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CitedBy_id	crossref_primary_10_1016_j_chembiol_2012_07_011 crossref_primary_10_1089_nat_2017_0702 crossref_primary_10_1021_acs_accounts_0c00078 crossref_primary_10_1002_0471142700_nc1603s39 crossref_primary_10_1080_10426507_2010_538456 crossref_primary_10_1517_14712598_2015_983070 crossref_primary_10_2174_1389450124666230329123409 crossref_primary_10_1021_ja511145h
Cites_doi	10.1016/0040-4020(96)00906-4 10.1093/nar/27.20.4071 10.1093/nar/gkg439 10.1093/nar/25.18.3629 10.1021/bi960318x 10.1021/ja027983f 10.1021/jm031045o 10.2174/0929867013372391
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SubjectTerms	DNA - chemical synthesis DNA - chemistry DNA - metabolism Esterification Flow Cytometry HeLa Cells Humans Jurkat Cells Lipids - chemistry Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Heteroduplexes - metabolism Oligonucleotides - chemistry Oligonucleotides - metabolism passive delivery Phosphonoacetic Acid - analogs & derivatives Phosphonoacetic Acid - chemical synthesis Phosphonoacetic Acid - chemistry Phosphonoacetic Acid - metabolism Phosphonocarboxylate oligonucleotides RNA - chemistry RNA - metabolism Transfection
Title	Synthesis and Biological Activity of Phosphonocarboxylate DNA
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