Synthesis and Biological Activity of Phosphonocarboxylate DNA

Oligodeoxynucleotides containing internucleotide phosphonoacetate esters are taken up irreversibly by cells in culture in the absence of cationic lipids. These oligonucleotides also are active in stimulating RNase H and are stable toward nucleases.

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Bibliographic Details
Published in:	Nucleosides, nucleotides & nucleic acids Vol. 26; no. 6-7; pp. 539 - 546
Main Authors:	Yamada, Christina M., Dellinger, Douglas J., Caruthers, Marvin H.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis Group 01-01-2007
Subjects:	DNA - chemical synthesis DNA - chemistry DNA - metabolism Esterification Flow Cytometry HeLa Cells Humans Jurkat Cells Lipids - chemistry Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Heteroduplexes - metabolism Oligonucleotides - chemistry Oligonucleotides - metabolism passive delivery Phosphonoacetic Acid - analogs & derivatives Phosphonoacetic Acid - chemical synthesis Phosphonoacetic Acid - chemistry Phosphonoacetic Acid - metabolism Phosphonocarboxylate oligonucleotides RNA - chemistry RNA - metabolism Transfection
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Description
Summary:	Oligodeoxynucleotides containing internucleotide phosphonoacetate esters are taken up irreversibly by cells in culture in the absence of cationic lipids. These oligonucleotides also are active in stimulating RNase H and are stable toward nucleases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1525-7770 1532-2335
DOI:	10.1080/15257770701489896