The ketogenic diet does not alter brain expression of orexigenic neuropeptides

• Published in: Epilepsy research Vol. 62; no. 1; pp. 35 - 39
• Main Authors: Tabb, Kroshona, Szot, Patricia, White, Sylvia S., Liles, L. Cameron, Weinshenker, David
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-11-2004; Elsevier
• Subjects: 3-Hydroxybutyric Acid - blood; Animals; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Brain Chemistry - drug effects; Diseases of the nervous system; Eating - physiology; Energy Metabolism - physiology; Epilepsy - diet therapy; Galanin; Galanin - biosynthesis; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; In Situ Hybridization; Ketogenic diet; Ketones - metabolism; Medical sciences; Mice; Mice, Inbred C57BL; Nervous system (semeiology, syndromes); Neurology; Neuropeptide Y - biosynthesis; Neuropharmacology; NPY; Pharmacology. Drug treatments; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Seizures - chemically induced; Seizures - diet therapy; Galanin; NPY; Ketogenic diet; Nervous system diseases; Epilepsy; Central nervous system disease; Neuropeptide; Cerebral disorder
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2004.08.002

Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ hybridization revealed no effect of the KD on NPY or galanin mRNA expression, suggesting that increased expression of NPY and galanin do not contribute to the anticonvulsant effect of the KD.