Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight
Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ketogenic diet (VLCKD) modulates the inflammatory a...
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| Published in: | Clinical nutrition (Edinburgh, Scotland) Vol. 41; no. 7; pp. 1566 - 1577 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-07-2022
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| Abstract | Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ketogenic diet (VLCKD) modulates the inflammatory and oxidative stress profile, compared with a standard, balanced hypocaloric diet (LCD) or bariatric surgery (BS) in patients with obesity.
The study was performed in 79 patients with overweight or obesity and 32 normal-weight volunteers as the control group. Patients with obesity underwent a weight reduction therapy based on VLCKD, LCD or BS. The quantification of the circulating levels of a multiplexing test of cytokines and carcinogenesis/aging biomarkers, as well as of lipid peroxides and total antioxidant power, was carried out.
First, we observed that pro-inflammatory cytokines increase, while anti-inflammatory cytokines decrease under excessive body weight. Relevantly, when patients underwent weight loss strategies, it was shown that energy-restricted and surgical strategies of weight loss induced changes in circulating cytokine and lipid peroxides. This effect was more notable in patients following the VLCKD than the LCD or BS and it was observed mainly in the ketosis phase of the intervention. Particularly, IL-11, IL-12, IL-2, INF-γ, INF-β, Pentraxin-3 or MMP1 changed after VLCKD. Whereas, APRIL, TWEAK, osteocalcin and IL-28A increased after BS.
As far as we know, this is the first study that evaluate the time-course of cytokines and oxidative stress markers after a VLCKD as compared with a standard LCD and BS. The observed results support the immunomodulatory effect of nutritional ketosis induced by a VLCKD synergistically with weight loss as a strategy to improve innate-immunity and to prevent infections and carcinogenesis in patients with obesity. |
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| AbstractList | Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ketogenic diet (VLCKD) modulates the inflammatory and oxidative stress profile, compared with a standard, balanced hypocaloric diet (LCD) or bariatric surgery (BS) in patients with obesity.
The study was performed in 79 patients with overweight or obesity and 32 normal-weight volunteers as the control group. Patients with obesity underwent a weight reduction therapy based on VLCKD, LCD or BS. The quantification of the circulating levels of a multiplexing test of cytokines and carcinogenesis/aging biomarkers, as well as of lipid peroxides and total antioxidant power, was carried out.
First, we observed that pro-inflammatory cytokines increase, while anti-inflammatory cytokines decrease under excessive body weight. Relevantly, when patients underwent weight loss strategies, it was shown that energy-restricted and surgical strategies of weight loss induced changes in circulating cytokine and lipid peroxides. This effect was more notable in patients following the VLCKD than the LCD or BS and it was observed mainly in the ketosis phase of the intervention. Particularly, IL-11, IL-12, IL-2, INF-γ, INF-β, Pentraxin-3 or MMP1 changed after VLCKD. Whereas, APRIL, TWEAK, osteocalcin and IL-28A increased after BS.
As far as we know, this is the first study that evaluate the time-course of cytokines and oxidative stress markers after a VLCKD as compared with a standard LCD and BS. The observed results support the immunomodulatory effect of nutritional ketosis induced by a VLCKD synergistically with weight loss as a strategy to improve innate-immunity and to prevent infections and carcinogenesis in patients with obesity. BACKGROUND & AIMInflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ketogenic diet (VLCKD) modulates the inflammatory and oxidative stress profile, compared with a standard, balanced hypocaloric diet (LCD) or bariatric surgery (BS) in patients with obesity. METHODSThe study was performed in 79 patients with overweight or obesity and 32 normal-weight volunteers as the control group. Patients with obesity underwent a weight reduction therapy based on VLCKD, LCD or BS. The quantification of the circulating levels of a multiplexing test of cytokines and carcinogenesis/aging biomarkers, as well as of lipid peroxides and total antioxidant power, was carried out. RESULTSFirst, we observed that pro-inflammatory cytokines increase, while anti-inflammatory cytokines decrease under excessive body weight. Relevantly, when patients underwent weight loss strategies, it was shown that energy-restricted and surgical strategies of weight loss induced changes in circulating cytokine and lipid peroxides. This effect was more notable in patients following the VLCKD than the LCD or BS and it was observed mainly in the ketosis phase of the intervention. Particularly, IL-11, IL-12, IL-2, INF-γ, INF-β, Pentraxin-3 or MMP1 changed after VLCKD. Whereas, APRIL, TWEAK, osteocalcin and IL-28A increased after BS. CONCLUSIONAs far as we know, this is the first study that evaluate the time-course of cytokines and oxidative stress markers after a VLCKD as compared with a standard LCD and BS. The observed results support the immunomodulatory effect of nutritional ketosis induced by a VLCKD synergistically with weight loss as a strategy to improve innate-immunity and to prevent infections and carcinogenesis in patients with obesity. |
| Author | Baltar, Javier Castro, Ana I. Abete, Itziar Lorenzo, Paula M. Zulet, M Angeles Casanueva, Felipe F. Tinahones, Francisco J. Crujeiras, Ana B. Martinez, J Alfredo Portillo, María P. Sajoux, Ignacio Gomez-Arbelaez, Diego Izquierdo, Andrea G. |
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| Cites_doi | 10.1016/j.freeradbiomed.2011.05.010 10.1155/2020/6401341 10.2903/j.efsa.2015.3957 10.1016/j.ejphar.2020.173329 10.1016/S0140-6736(17)32129-3 10.1038/nrendo.2012.49 10.1007/s11695-015-1802-8 10.3389/fendo.2019.00540 10.15252/emmm.202114323 10.1038/s41416-021-01393-y 10.3390/ijerph18168475 10.1016/j.arcmed.2009.03.005 10.4254/wjh.v11.i3.305 10.1210/jc.2014-3415 10.1210/jc.2009-2128 10.1155/2015/716315 10.1039/D0FO01984D 10.21037/tau.2018.08.09 10.3390/nu10101348 10.1038/ijo.2017.138 10.1210/er.2017-00253 10.1038/s41366-021-01035-6 10.1186/s13148-019-0790-2 10.1089/ars.2021.0054 10.1007/s11154-020-09567-4 10.3945/an.116.014506 10.3390/ijms12053117 10.1089/met.2015.0095 10.1002/jmv.26237 10.1007/s11695-021-05815-x 10.3390/nu11102368 10.1038/nm.3804 10.1007/s00394-009-0019-9 10.1089/rej.2007.0540 10.3390/ijms21093228 10.1039/D1FO01278A 10.3389/fimmu.2019.00837 10.1186/s12916-021-02185-0 10.2147/VHRM.S103877 10.1089/omi.2008.0001 10.3390/nu13093010 10.1186/s12920-019-0522-7 10.1002/cncr.31538 10.1038/nutd.2016.36 10.3389/fbioe.2020.00006 10.1007/s12020-016-0964-z 10.1038/s41598-020-60814-9 10.1371/journal.pone.0228633 10.1038/ijo.2015.208 10.1038/nrrheum.2017.22 10.3389/fphys.2018.01307 10.1002/jpen.2226 10.1056/NEJMsr1606602 10.3390/cancers13184688 10.1080/10408398.2020.1818053 10.3390/nu13103420 10.1007/s12020-016-1050-2 10.12965/jer.1734920.490 10.1002/oby.20695 10.3390/cancers13040866 10.1186/s12933-017-0604-9 10.3390/nu14010033 10.1007/s12020-014-0192-3 10.1016/j.clnu.2021.05.010 |
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| Keywords | Obesity Oxidative stress Inflammation Immunonutrition PnK method Nutritional ketosis |
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| References | Bradshaw, Seeds, Miller, Mahajan, Curtis (bib32) 2020; 2020 Hirschberger, Strauß, Effinger, Marstaller, Ferstl, Müller (bib44) 2021; 13 Martínez, Meli, Candia, Filippi, Vilallonga, Cordero (bib23) 2022; 32 (bib1) 2017; 390 Moreno, Bellido, Sajoux, Goday, Saavedra, Crujeiras (bib36) 2014; 47 Crujeiras, Izquierdo, Primo, Milagro, Sajoux, Jácome (bib21) 2021; 40 Wang, Chen, Xiao (bib31) 2021; 13 Andersen, Goyal, Weiss, Westbrook, Maddocks, Byrd (bib52) 2018; 124 Bonaroti, Abdelhamid, Kar, Sperry, Zamora, Namas (bib45) 2021; 35 Fraszczyk, Luijten, Spijkerman, Snieder, Wackers, Bloks (bib58) 2020; 12 Ristow, Schmeisser (bib64) 2011; 51 Di Domenico, Pinto, Quagliuolo, Contaldo, Settembre, Romano (bib43) 2019; 10 Croft, Siegel (bib50) 2017; 13 Yang, Hu, Zhu (bib11) 2021; 93 Abete, Goyenechea, Crujeiras, Martínez (bib40) 2009; 40 Cava, Yeat, Mittendorfer (bib22) 2017; 8 Nicoletti, Pinhel, Diaz-Lagares, Casanueva, Jácome, Pinhanelli (bib25) 2019; 12 Faria, Ritter, Gasparetti, Corrêa, Brunelli, Almeida (bib10) 2019; 112 Manna, Jain (bib62) 2015; 13 Karam, Chavez-Moreno, Koh, Akar, Akar (bib61) 2017; 16 Goday, Bellido, Sajoux, Crujeiras, Burguera, García-Luna (bib65) 2016; 6 Crujeiras, Cabia, Carreira, Amil, Cueva, Andrade (bib5) 2016; 40 Nicoletti, Nonino, de Oliveira, Pinhel, Mansego, Milagro (bib57) 2016 O'Shea, Hogan (bib46) 2019; 11 Crujeiras, Parra, Goyenechea, Abete, Martínez (bib41) 2009; 48 Youm, Nguyen, Grant, Goldberg, Bodogai, Kim (bib34) 2015; 21 Pedersen, Febbraio (bib16) 2012; 8 Jaoude, Koh (bib49) 2016; 12 Bandera-Merchan, Boughanem, Crujeiras, Macias-Gonzalez, Tinahones (bib68) 2020; 21 Crujeiras, Gomez-Arbelaez, Zulet, Carreira, Sajoux, de Luis (bib24) 2017; 41 Dos Santos Ferreira, Dos Santos, Maranhão Mendonça, Espinola Carvalho, Franco (bib27) 2021; 12 Reguero, Gómez de Cedrón, Wagner, Reglero, Quintela, Ramírez de Molina (bib26) 2021; 13 Izquierdo, Carreira, Boughanem, Moreno-Navarrete, Nicoletti, Oliver (bib55) 2021 Altuna-Coy, Ruiz-Plazas, Alves-Santiago, Segarra-Tomás, Chacón (bib51) 2021; 13 Dias-Audibert, Navarro, de Oliveira, Delafiori, Melo, Guerreiro (bib8) 2020; 8 El-Missiry, El-Missiry, Othman (bib12) 2020; 882 Crujeiras, Parra, Milagro, Goyenechea, Larrarte, Margareto (bib14) 2008; 12 Tunc-Ata, Turgut, Mergen-Dalyanoglu, Turgut (bib48) 2017; 13 Nazarewicz, Ziolkowski, Vaccaro, Ghafourifar (bib63) 2007; 10 Gomez-Arbelaez, Bellido, Castro, Ordoñez-Mayan, Carreira, Galban (bib15) 2016; 102 Izaola, de Luis, Sajoux, Domingo, Vidal (bib7) 2015; 31 Arrieta, Martinez-Vaello, Bengoa, Rosillo, de Pablo, Voguel (bib53) 2021; 13 Ruiz-León, Lapuente, Estruch, Casas (bib28) 2019; 10 Pugliese, Liccardi, Graziadio, Barrea, Muscogiuri, Colao (bib13) 2022; 46 Bjurlin, Smith, Huang (bib29) 2018; 7 Nicoletti, Pinhel, Noronha, de Oliveira, Salgado Junior, Jácome (bib56) 2020; 10 Witasp, Carrero, Michaëlsson, Ahlström, Kullberg, Adamsson (bib47) 2014; 22 Lauby-Secretan, Scoccianti, Loomis, Grosse, Bianchini, Straif (bib4) 2016; 375 Barrea, Caprio, Tuccinardi, Moriconi, Di Renzo, Muscogiuri (bib67) 2020 Mundi, Mohamed Elfadil, Patel, Patel, Hurt (bib70) 2021; 45 Russell, Zhang, Gillanders, Bartlett, Fisk, Calder (bib30) 2019; 11 Heber, Greenway, Kaplan, Livingston, Salvador, Still (bib39) 2010; 95 Bray, Heisel, Afshin, Jensen, Dietz, Long (bib3) 2018; 39 Rubinstein, Brown, Iyengar (bib6) 2021; 125 Polito, Valenzano, Scarinci, Villano, Monda, Messina (bib19) 2021; 18 MacDonald, Liu, Huang, Kuo, Tsai, Tang (bib42) 2019; 20 Leal, Lopes, Batista (bib17) 2018; 9 Kolb, Kempf, Röhling, Lenzen-Schulte, Schloot, Martin (bib33) 2021; 19 Elisia, Lam, Cho, Hay, Li, Kapeluto (bib9) 2020; 15 Moreno, Crujeiras, Bellido, Sajoux, Casanueva (bib37) 2016; 54 Apovian, Aronne, Bessesen, McDonnell, Murad, Pagotto (bib2) 2015; 100 Castro, Gomez-Arbelaez, Crujeiras, Granero, Aguera, Jimenez-Murcia (bib20) 2018; 10 Fernández-Sánchez, Madrigal-Santillán, Bautista, Esquivel-Soto, Morales-González, Esquivel-Chirino (bib60) 2011; 12 Sajoux, Lorenzo, Gomez-Arbelaez, Zulet, Abete, Castro (bib18) 2019; 11 Sánchez, Santos, Nuñez-Garcia, Bueno, Sajoux, Yeramian (bib66) 2021; 14 Monda, Polito, Lovino, Finaldi, Valenzano, Nigro (bib72) 2020; 21 Valenzano, Tartaglia, Ambrosi, Tafuri, Monda, Messina (bib59) 2020; 9 (bib38) 2015; 13 Meng, Yang, Yu, Zhu (bib54) 2015; 2015 de Luis, Domingo, Izaola, Casanueva, Bellido, Sajoux (bib35) 2016; 54 Lorenzo, Crujeiras (bib69) 2021; 12 Barrea, Megna, Cacciapuoti, Frias-Toral, Fabbrocini, Savastano (bib71) 2022; 62 Witasp (10.1016/j.clnu.2022.05.007_bib47) 2014; 22 Faria (10.1016/j.clnu.2022.05.007_bib10) 2019; 112 Castro (10.1016/j.clnu.2022.05.007_bib20) 2018; 10 Crujeiras (10.1016/j.clnu.2022.05.007_bib24) 2017; 41 Bjurlin (10.1016/j.clnu.2022.05.007_bib29) 2018; 7 Martínez (10.1016/j.clnu.2022.05.007_bib23) 2022; 32 Bradshaw (10.1016/j.clnu.2022.05.007_bib32) 2020; 2020 Leal (10.1016/j.clnu.2022.05.007_bib17) 2018; 9 Jaoude (10.1016/j.clnu.2022.05.007_bib49) 2016; 12 Di Domenico (10.1016/j.clnu.2022.05.007_bib43) 2019; 10 Izaola (10.1016/j.clnu.2022.05.007_bib7) 2015; 31 (10.1016/j.clnu.2022.05.007_bib38) 2015; 13 Crujeiras (10.1016/j.clnu.2022.05.007_bib5) 2016; 40 Goday (10.1016/j.clnu.2022.05.007_bib65) 2016; 6 Valenzano (10.1016/j.clnu.2022.05.007_bib59) 2020; 9 Apovian (10.1016/j.clnu.2022.05.007_bib2) 2015; 100 Bonaroti (10.1016/j.clnu.2022.05.007_bib45) 2021; 35 Elisia (10.1016/j.clnu.2022.05.007_bib9) 2020; 15 Croft (10.1016/j.clnu.2022.05.007_bib50) 2017; 13 Moreno (10.1016/j.clnu.2022.05.007_bib37) 2016; 54 Heber (10.1016/j.clnu.2022.05.007_bib39) 2010; 95 Yang (10.1016/j.clnu.2022.05.007_bib11) 2021; 93 Reguero (10.1016/j.clnu.2022.05.007_bib26) 2021; 13 Monda (10.1016/j.clnu.2022.05.007_bib72) 2020; 21 Polito (10.1016/j.clnu.2022.05.007_bib19) 2021; 18 Bandera-Merchan (10.1016/j.clnu.2022.05.007_bib68) 2020; 21 O'Shea (10.1016/j.clnu.2022.05.007_bib46) 2019; 11 Sánchez (10.1016/j.clnu.2022.05.007_bib66) 2021; 14 Nicoletti (10.1016/j.clnu.2022.05.007_bib57) 2016 Abete (10.1016/j.clnu.2022.05.007_bib40) 2009; 40 Russell (10.1016/j.clnu.2022.05.007_bib30) 2019; 11 Rubinstein (10.1016/j.clnu.2022.05.007_bib6) 2021; 125 Crujeiras (10.1016/j.clnu.2022.05.007_bib14) 2008; 12 Moreno (10.1016/j.clnu.2022.05.007_bib36) 2014; 47 Manna (10.1016/j.clnu.2022.05.007_bib62) 2015; 13 Sajoux (10.1016/j.clnu.2022.05.007_bib18) 2019; 11 Pugliese (10.1016/j.clnu.2022.05.007_bib13) 2022; 46 Barrea (10.1016/j.clnu.2022.05.007_bib71) 2022; 62 El-Missiry (10.1016/j.clnu.2022.05.007_bib12) 2020; 882 Youm (10.1016/j.clnu.2022.05.007_bib34) 2015; 21 Meng (10.1016/j.clnu.2022.05.007_bib54) 2015; 2015 Kolb (10.1016/j.clnu.2022.05.007_bib33) 2021; 19 (10.1016/j.clnu.2022.05.007_bib1) 2017; 390 de Luis (10.1016/j.clnu.2022.05.007_bib35) 2016; 54 Andersen (10.1016/j.clnu.2022.05.007_bib52) 2018; 124 Dos Santos Ferreira (10.1016/j.clnu.2022.05.007_bib27) 2021; 12 Fernández-Sánchez (10.1016/j.clnu.2022.05.007_bib60) 2011; 12 Cava (10.1016/j.clnu.2022.05.007_bib22) 2017; 8 Nicoletti (10.1016/j.clnu.2022.05.007_bib56) 2020; 10 Bray (10.1016/j.clnu.2022.05.007_bib3) 2018; 39 Arrieta (10.1016/j.clnu.2022.05.007_bib53) 2021; 13 Ruiz-León (10.1016/j.clnu.2022.05.007_bib28) 2019; 10 Nazarewicz (10.1016/j.clnu.2022.05.007_bib63) 2007; 10 Fraszczyk (10.1016/j.clnu.2022.05.007_bib58) 2020; 12 Lauby-Secretan (10.1016/j.clnu.2022.05.007_bib4) 2016; 375 Mundi (10.1016/j.clnu.2022.05.007_bib70) 2021; 45 Hirschberger (10.1016/j.clnu.2022.05.007_bib44) 2021; 13 Altuna-Coy (10.1016/j.clnu.2022.05.007_bib51) 2021; 13 Crujeiras (10.1016/j.clnu.2022.05.007_bib41) 2009; 48 MacDonald (10.1016/j.clnu.2022.05.007_bib42) 2019; 20 Pedersen (10.1016/j.clnu.2022.05.007_bib16) 2012; 8 Barrea (10.1016/j.clnu.2022.05.007_bib67) 2020 Gomez-Arbelaez (10.1016/j.clnu.2022.05.007_bib15) 2016; 102 Crujeiras (10.1016/j.clnu.2022.05.007_bib21) 2021; 40 Tunc-Ata (10.1016/j.clnu.2022.05.007_bib48) 2017; 13 Ristow (10.1016/j.clnu.2022.05.007_bib64) 2011; 51 Lorenzo (10.1016/j.clnu.2022.05.007_bib69) 2021; 12 Wang (10.1016/j.clnu.2022.05.007_bib31) 2021; 13 Nicoletti (10.1016/j.clnu.2022.05.007_bib25) 2019; 12 Dias-Audibert (10.1016/j.clnu.2022.05.007_bib8) 2020; 8 Izquierdo (10.1016/j.clnu.2022.05.007_bib55) 2021 Karam (10.1016/j.clnu.2022.05.007_bib61) 2017; 16 |
| References_xml | – volume: 39 start-page: 79 year: 2018 end-page: 132 ident: bib3 article-title: The science of obesity management: an endocrine society scientific statement publication-title: Endocr Rev contributor: fullname: Long – volume: 13 year: 2021 ident: bib31 article-title: β-Hydroxybutyrate as an anti-aging metabolite publication-title: Nutrients contributor: fullname: Xiao – volume: 35 start-page: 1393 year: 2021 end-page: 1406 ident: bib45 article-title: The use of multiplexing to identify cytokine and chemokine networks in the immune-inflammatory response to trauma publication-title: Antioxidants Redox Signal contributor: fullname: Namas – volume: 11 year: 2019 ident: bib46 article-title: Dysregulation of natural killer cells in obesity publication-title: Cancers contributor: fullname: Hogan – volume: 8 start-page: 511 year: 2017 end-page: 519 ident: bib22 article-title: Preserving healthy muscle during weight loss publication-title: Adv Nutr contributor: fullname: Mittendorfer – volume: 2020 start-page: 6401341 year: 2020 ident: bib32 article-title: COVID-19: proposing a ketone-based metabolic therapy as a treatment to blunt the cytokine storm publication-title: Oxid Med Cell Longev contributor: fullname: Curtis – volume: 19 start-page: 313 year: 2021 ident: bib33 article-title: Ketone bodies: from enemy to friend and guardian angel publication-title: BMC Med contributor: fullname: Martin – volume: 100 start-page: 342 year: 2015 end-page: 362 ident: bib2 article-title: Pharmacological management of obesity: an endocrine Society clinical practice guideline publication-title: J Clin Endocrinol Metab contributor: fullname: Pagotto – volume: 375 start-page: 794 year: 2016 end-page: 798 ident: bib4 article-title: Body fatness and cancer--viewpoint of the IARC working group publication-title: N Engl J Med contributor: fullname: Straif – volume: 21 start-page: 263 year: 2015 end-page: 269 ident: bib34 article-title: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease publication-title: Nat Med contributor: fullname: Kim – volume: 40 start-page: 306 year: 2009 end-page: 310 ident: bib40 article-title: Inflammatory state and stress condition in weight-lowering Lys109Arg LEPR gene polymorphism carriers publication-title: Arch Med Res contributor: fullname: Martínez – volume: 882 start-page: 173329 year: 2020 ident: bib12 article-title: Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19 publication-title: Eur J Pharmacol contributor: fullname: Othman – volume: 12 start-page: 14 year: 2020 ident: bib58 article-title: The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients publication-title: Clin Epigenet contributor: fullname: Bloks – volume: 22 start-page: 1373 year: 2014 end-page: 1379 ident: bib47 article-title: Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots and weight loss publication-title: Obesity contributor: fullname: Adamsson – volume: 2015 start-page: 716315 year: 2015 ident: bib54 article-title: EPSTI1 is involved in IL-28a-mediated inhibition of HCV infection publication-title: Mediat Inflamm contributor: fullname: Zhu – start-page: 1 year: 2020 end-page: 22 ident: bib67 article-title: Could ketogenic diet “starve” cancer? Emerging evidence publication-title: Crit Rev Food Sci Nutr contributor: fullname: Muscogiuri – volume: 47 start-page: 793 year: 2014 end-page: 805 ident: bib36 article-title: Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity publication-title: Endocrine contributor: fullname: Crujeiras – volume: 31 start-page: 2352 year: 2015 end-page: 2358 ident: bib7 article-title: Inflamación y obesidad (Lipoinflamación) publication-title: Nutr Hosp contributor: fullname: Vidal – volume: 10 year: 2019 ident: bib28 article-title: Clinical advances in immunonutrition and atherosclerosis: a review publication-title: Front Immunol contributor: fullname: Casas – volume: 125 start-page: 495 year: 2021 end-page: 509 ident: bib6 article-title: Targeting obesity-related dysfunction in hormonally driven cancers publication-title: Br J Cancer contributor: fullname: Iyengar – volume: 8 year: 2020 ident: bib8 article-title: Combining machine learning and metabolomics to identify weight gain biomarkers publication-title: Front Bioeng Biotechnol contributor: fullname: Guerreiro – volume: 11 start-page: 305 year: 2019 end-page: 317 ident: bib30 article-title: Preoperative immunonutrition in patients undergoing liver resection: a prospective randomized trial publication-title: World J Hepatol contributor: fullname: Calder – volume: 13 start-page: 279 year: 2017 end-page: 283 ident: bib48 article-title: Examination of levels pentraxin-3, interleukin-6, and C-reactive protein in rat model acute and chronic exercise publication-title: J Exerc Rehabil contributor: fullname: Turgut – volume: 13 year: 2021 ident: bib51 article-title: Serum levels of the cytokine TWEAK are associated with metabolic status in patients with prostate cancer and modulate cancer cell lipid metabolism in vitro publication-title: Cancers contributor: fullname: Chacón – volume: 102 start-page: 2016 year: 2016 end-page: 2385 ident: bib15 article-title: Body composition changes after very low-calorie-ketogenic diet in obesity evaluated by three standardized methods publication-title: J Clin Endocrinol Metab contributor: fullname: Galban – volume: 40 start-page: 3959 year: 2021 end-page: 3972 ident: bib21 article-title: Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity publication-title: Clin Nutr contributor: fullname: Jácome – volume: 390 start-page: 2627 year: 2017 end-page: 2642 ident: bib1 article-title: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults publication-title: Lancet (London, England) – volume: 54 start-page: 681 year: 2016 end-page: 690 ident: bib37 article-title: Obesity treatment by very low-calorie-ketogenic diet at two years: reduction in visceral fat and on the burden of disease publication-title: Endocrine contributor: fullname: Casanueva – volume: 45 start-page: 26 year: 2021 end-page: 32 ident: bib70 article-title: Ketogenic diet and cancer: fad or fabulous? publication-title: JPEN - J Parenter Enter Nutr contributor: fullname: Hurt – volume: 13 start-page: 217 year: 2017 end-page: 233 ident: bib50 article-title: Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases publication-title: Nat Rev Rheumatol contributor: fullname: Siegel – volume: 21 year: 2020 ident: bib72 article-title: Short-term physiological effects of a very low-calorie ketogenic diet: effects on adiponectin levels and inflammatory states publication-title: Int J Mol Sci contributor: fullname: Nigro – volume: 11 start-page: 2368 year: 2019 ident: bib18 article-title: Effect of a very-low-calorie ketogenic diet on circulating myokine levels compared with the effect of bariatric surgery or a low-calorie diet in patients with obesity publication-title: Nutrients contributor: fullname: Castro – volume: 13 year: 2021 ident: bib53 article-title: Stress hyperglycemia and osteocalcin in COVID-19 critically ill patients on artificial nutrition publication-title: Nutrients contributor: fullname: Voguel – volume: 7 start-page: S760 year: 2018 end-page: S762 ident: bib29 article-title: Impact of immunonutrition on radical cystectomy immunoresponse and outcomes; opportunity for peri-operative optimization publication-title: Transl Androl Urol contributor: fullname: Huang – volume: 12 start-page: 72 year: 2019 ident: bib25 article-title: DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se publication-title: BMC Med Genom contributor: fullname: Pinhanelli – volume: 41 start-page: 1570 year: 2017 end-page: 1578 ident: bib24 article-title: Plasma FGF21 levels in obese patients undergoing energy-restricted diets or bariatric surgery: a marker of metabolic stress? publication-title: Int J Obes contributor: fullname: de Luis – volume: 12 start-page: 251 year: 2008 end-page: 261 ident: bib14 article-title: Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study publication-title: OMICS A J Integr Biol contributor: fullname: Margareto – volume: 95 start-page: 4823 year: 2010 end-page: 4843 ident: bib39 article-title: Endocrine and nutritional management of the post-bariatric surgery patient: an endocrine society clinical practice guideline publication-title: J Clin Endocrinol Metab contributor: fullname: Still – volume: 124 start-page: 3240 year: 2018 end-page: 3248 ident: bib52 article-title: Cells, cytokines, chemokines, and cancer stress: a biobehavioral study of patients with chronic lymphocytic leukemia publication-title: Cancer contributor: fullname: Byrd – volume: 16 start-page: 120 year: 2017 ident: bib61 article-title: Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes publication-title: Cardiovasc Diabetol contributor: fullname: Akar – volume: 13 year: 2021 ident: bib26 article-title: Precision nutrition to activate thermogenesis as a complementary approach to target obesity and associated-metabolic-disorders publication-title: Cancers contributor: fullname: Ramírez de Molina – volume: 13 start-page: 3957 year: 2015 ident: bib38 article-title: Scientific Opinion on the essential composition of total diet replacements for weight control publication-title: EFSA J – volume: 10 start-page: 435 year: 2007 end-page: 440 ident: bib63 article-title: Effect of short-term ketogenic diet on redox status of human blood publication-title: Rejuvenation Res contributor: fullname: Ghafourifar – volume: 12 start-page: 287 year: 2016 end-page: 295 ident: bib49 article-title: Matrix metalloproteinases in exercise and obesity publication-title: Vasc Health Risk Manag contributor: fullname: Koh – volume: 21 start-page: 509 year: 2020 end-page: 519 ident: bib68 article-title: Ketotherapy as an epigenetic modifier in cancer publication-title: Rev Endocr Metab Disord contributor: fullname: Tinahones – volume: 6 year: 2016 ident: bib65 article-title: Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus publication-title: Nutr Diabetes contributor: fullname: García-Luna – volume: 51 start-page: 327 year: 2011 end-page: 336 ident: bib64 article-title: Extending life span by increasing oxidative stress publication-title: Free Radic Biol Med contributor: fullname: Schmeisser – volume: 18 year: 2021 ident: bib19 article-title: Very low-calorie ketogenic diet modulates the autonomic nervous system Activity through salivary amylase in obese population subjects publication-title: Int J Environ Res Publ Health contributor: fullname: Messina – start-page: e13685 year: 2021 ident: bib55 article-title: Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss publication-title: Eur J Clin Invest contributor: fullname: Oliver – volume: 12 start-page: 7637 year: 2021 end-page: 7650 ident: bib27 article-title: Immunonutrition effects on coping with COVID-19 publication-title: Food Funct contributor: fullname: Franco – volume: 9 year: 2020 ident: bib59 article-title: The metabolic rearrangements of bariatric surgery: focus on orexin-A and the adiponectin system publication-title: J Clin Med contributor: fullname: Messina – volume: 54 start-page: 111 year: 2016 end-page: 122 ident: bib35 article-title: Effect of DHA supplementation in a very low-calorie ketogenic diet in the treatment of obesity: a randomized clinical trial publication-title: Endocrine contributor: fullname: Sajoux – volume: 46 start-page: 449 year: 2022 end-page: 465 ident: bib13 article-title: Obesity and infectious diseases: pathophysiology and epidemiology of a double pandemic condition publication-title: Int J Obes contributor: fullname: Colao – volume: 12 start-page: 3117 year: 2011 end-page: 3132 ident: bib60 article-title: Inflammation, oxidative stress, and obesity publication-title: Int J Mol Sci contributor: fullname: Esquivel-Chirino – volume: 8 start-page: 457 year: 2012 end-page: 465 ident: bib16 article-title: Muscles , exercise and obesity : skeletal muscle publication-title: Nat Rev Endocrinol contributor: fullname: Febbraio – volume: 12 start-page: 1402 year: 2021 end-page: 1414 ident: bib69 article-title: Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks publication-title: Food Funct contributor: fullname: Crujeiras – volume: 48 start-page: 341 year: 2009 end-page: 347 ident: bib41 article-title: Tachyphylaxis effects on postprandial oxidative stress and mitochondrial-related gene expression in overweight subjects after a period of energy restriction publication-title: Eur J Nutr contributor: fullname: Martínez – volume: 15 year: 2020 ident: bib9 article-title: Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk publication-title: PLoS One contributor: fullname: Kapeluto – volume: 13 start-page: 423 year: 2015 end-page: 444 ident: bib62 article-title: Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies publication-title: Metab Syndr Relat Disord contributor: fullname: Jain – volume: 14 year: 2021 ident: bib66 article-title: Randomized clinical trial to evaluate the morphological changes in the adventitial vasa vasorum density and biological markers of endothelial dysfunction in subjects with moderate obesity undergoing a very low-calorie ketogenic diet publication-title: Nutrients contributor: fullname: Yeramian – volume: 13 year: 2021 ident: bib44 article-title: Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming publication-title: EMBO Mol Med contributor: fullname: Müller – volume: 112 start-page: 383 year: 2019 end-page: 389 ident: bib10 article-title: A proposed inflammatory score of circulating cytokines/adipokines associated with resistant hypertension, but dependent on obesity parameters publication-title: Arq Bras Cardiol contributor: fullname: Almeida – volume: 32 start-page: 625 year: 2022 end-page: 633 ident: bib23 article-title: The impact of bariatric surgery on the muscle mass in patients with obesity: 2-year follow-up publication-title: Obes Surg contributor: fullname: Cordero – volume: 20 year: 2019 ident: bib42 article-title: Associations between adipokines in arthritic disease and implications for obesity publication-title: Int J Mol Sci contributor: fullname: Tang – volume: 40 start-page: 514 year: 2016 end-page: 523 ident: bib5 article-title: Secreted factors derived from obese visceral adipose tissue regulate the expression of breast malignant transformation genes publication-title: Int J Obes contributor: fullname: Andrade – volume: 10 year: 2018 ident: bib20 article-title: Effect of A Very low-calorie ketogenic diet on food and alcohol cravings, physical and sexual activity, sleep disturbances, and quality of life in obese patients publication-title: Nutrients contributor: fullname: Jimenez-Murcia – volume: 10 start-page: 6515 year: 2020 ident: bib56 article-title: Altered pathways in methylome and transcriptome longitudinal analysis of normal weight and bariatric surgery women publication-title: Sci Rep contributor: fullname: Jácome – start-page: 603 year: 2016 end-page: 611 ident: bib57 article-title: DNA methylation and hydroxymethylation levels in relation to two weight loss strategies: energy-restricted diet or bariatric surgery publication-title: Obes Surg contributor: fullname: Milagro – volume: 9 start-page: 1307 year: 2018 ident: bib17 article-title: Physical exercise-induced myokines and muscle-adipose tissue crosstalk: a review of current knowledge and the implications for health and metabolic diseases publication-title: Front Physiol contributor: fullname: Batista – volume: 10 year: 2019 ident: bib43 article-title: The role of oxidative stress and hormones in controlling obesity publication-title: Front Endocrinol contributor: fullname: Romano – volume: 62 start-page: 398 year: 2022 end-page: 414 ident: bib71 article-title: Very low-calorie ketogenic diet (VLCKD) in patients with psoriasis and obesity: an update for dermatologists and nutritionists publication-title: Crit Rev Food Sci Nutr contributor: fullname: Savastano – volume: 93 start-page: 257 year: 2021 end-page: 261 ident: bib11 article-title: Obesity aggravates COVID-19: a systematic review and meta-analysis publication-title: J Med Virol contributor: fullname: Zhu – volume: 51 start-page: 327 year: 2011 ident: 10.1016/j.clnu.2022.05.007_bib64 article-title: Extending life span by increasing oxidative stress publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2011.05.010 contributor: fullname: Ristow – volume: 2020 start-page: 6401341 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib32 article-title: COVID-19: proposing a ketone-based metabolic therapy as a treatment to blunt the cytokine storm publication-title: Oxid Med Cell Longev doi: 10.1155/2020/6401341 contributor: fullname: Bradshaw – volume: 13 start-page: 3957 year: 2015 ident: 10.1016/j.clnu.2022.05.007_bib38 article-title: Scientific Opinion on the essential composition of total diet replacements for weight control publication-title: EFSA J doi: 10.2903/j.efsa.2015.3957 – volume: 882 start-page: 173329 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib12 article-title: Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2020.173329 contributor: fullname: El-Missiry – volume: 390 start-page: 2627 year: 2017 ident: 10.1016/j.clnu.2022.05.007_bib1 article-title: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults publication-title: Lancet (London, England) doi: 10.1016/S0140-6736(17)32129-3 – volume: 8 start-page: 457 year: 2012 ident: 10.1016/j.clnu.2022.05.007_bib16 article-title: Muscles , exercise and obesity : skeletal muscle publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2012.49 contributor: fullname: Pedersen – start-page: 603 year: 2016 ident: 10.1016/j.clnu.2022.05.007_bib57 article-title: DNA methylation and hydroxymethylation levels in relation to two weight loss strategies: energy-restricted diet or bariatric surgery publication-title: Obes Surg doi: 10.1007/s11695-015-1802-8 contributor: fullname: Nicoletti – volume: 10 year: 2019 ident: 10.1016/j.clnu.2022.05.007_bib43 article-title: The role of oxidative stress and hormones in controlling obesity publication-title: Front Endocrinol doi: 10.3389/fendo.2019.00540 contributor: fullname: Di Domenico – volume: 13 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib44 article-title: Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming publication-title: EMBO Mol Med doi: 10.15252/emmm.202114323 contributor: fullname: Hirschberger – volume: 125 start-page: 495 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib6 article-title: Targeting obesity-related dysfunction in hormonally driven cancers publication-title: Br J Cancer doi: 10.1038/s41416-021-01393-y contributor: fullname: Rubinstein – volume: 18 issue: 16 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib19 article-title: Very low-calorie ketogenic diet modulates the autonomic nervous system Activity through salivary amylase in obese population subjects publication-title: Int J Environ Res Publ Health doi: 10.3390/ijerph18168475 contributor: fullname: Polito – volume: 40 start-page: 306 year: 2009 ident: 10.1016/j.clnu.2022.05.007_bib40 article-title: Inflammatory state and stress condition in weight-lowering Lys109Arg LEPR gene polymorphism carriers publication-title: Arch Med Res doi: 10.1016/j.arcmed.2009.03.005 contributor: fullname: Abete – start-page: e13685 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib55 article-title: Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss publication-title: Eur J Clin Invest contributor: fullname: Izquierdo – volume: 20 year: 2019 ident: 10.1016/j.clnu.2022.05.007_bib42 article-title: Associations between adipokines in arthritic disease and implications for obesity publication-title: Int J Mol Sci contributor: fullname: MacDonald – volume: 11 start-page: 305 year: 2019 ident: 10.1016/j.clnu.2022.05.007_bib30 article-title: Preoperative immunonutrition in patients undergoing liver resection: a prospective randomized trial publication-title: World J Hepatol doi: 10.4254/wjh.v11.i3.305 contributor: fullname: Russell – volume: 100 start-page: 342 year: 2015 ident: 10.1016/j.clnu.2022.05.007_bib2 article-title: Pharmacological management of obesity: an endocrine Society clinical practice guideline publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-3415 contributor: fullname: Apovian – volume: 95 start-page: 4823 year: 2010 ident: 10.1016/j.clnu.2022.05.007_bib39 article-title: Endocrine and nutritional management of the post-bariatric surgery patient: an endocrine society clinical practice guideline publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-2128 contributor: fullname: Heber – volume: 2015 start-page: 716315 year: 2015 ident: 10.1016/j.clnu.2022.05.007_bib54 article-title: EPSTI1 is involved in IL-28a-mediated inhibition of HCV infection publication-title: Mediat Inflamm doi: 10.1155/2015/716315 contributor: fullname: Meng – volume: 12 start-page: 1402 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib69 article-title: Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks publication-title: Food Funct doi: 10.1039/D0FO01984D contributor: fullname: Lorenzo – volume: 7 start-page: S760 year: 2018 ident: 10.1016/j.clnu.2022.05.007_bib29 article-title: Impact of immunonutrition on radical cystectomy immunoresponse and outcomes; opportunity for peri-operative optimization publication-title: Transl Androl Urol doi: 10.21037/tau.2018.08.09 contributor: fullname: Bjurlin – volume: 10 year: 2018 ident: 10.1016/j.clnu.2022.05.007_bib20 article-title: Effect of A Very low-calorie ketogenic diet on food and alcohol cravings, physical and sexual activity, sleep disturbances, and quality of life in obese patients publication-title: Nutrients doi: 10.3390/nu10101348 contributor: fullname: Castro – volume: 41 start-page: 1570 year: 2017 ident: 10.1016/j.clnu.2022.05.007_bib24 article-title: Plasma FGF21 levels in obese patients undergoing energy-restricted diets or bariatric surgery: a marker of metabolic stress? publication-title: Int J Obes doi: 10.1038/ijo.2017.138 contributor: fullname: Crujeiras – volume: 39 start-page: 79 year: 2018 ident: 10.1016/j.clnu.2022.05.007_bib3 article-title: The science of obesity management: an endocrine society scientific statement publication-title: Endocr Rev doi: 10.1210/er.2017-00253 contributor: fullname: Bray – volume: 46 start-page: 449 year: 2022 ident: 10.1016/j.clnu.2022.05.007_bib13 article-title: Obesity and infectious diseases: pathophysiology and epidemiology of a double pandemic condition publication-title: Int J Obes doi: 10.1038/s41366-021-01035-6 contributor: fullname: Pugliese – volume: 102 start-page: 2016 year: 2016 ident: 10.1016/j.clnu.2022.05.007_bib15 article-title: Body composition changes after very low-calorie-ketogenic diet in obesity evaluated by three standardized methods publication-title: J Clin Endocrinol Metab contributor: fullname: Gomez-Arbelaez – volume: 12 start-page: 14 issue: 1 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib58 article-title: The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients publication-title: Clin Epigenet doi: 10.1186/s13148-019-0790-2 contributor: fullname: Fraszczyk – volume: 35 start-page: 1393 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib45 article-title: The use of multiplexing to identify cytokine and chemokine networks in the immune-inflammatory response to trauma publication-title: Antioxidants Redox Signal doi: 10.1089/ars.2021.0054 contributor: fullname: Bonaroti – volume: 9 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib59 article-title: The metabolic rearrangements of bariatric surgery: focus on orexin-A and the adiponectin system publication-title: J Clin Med contributor: fullname: Valenzano – volume: 21 start-page: 509 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib68 article-title: Ketotherapy as an epigenetic modifier in cancer publication-title: Rev Endocr Metab Disord doi: 10.1007/s11154-020-09567-4 contributor: fullname: Bandera-Merchan – volume: 8 start-page: 511 issue: 3 year: 2017 ident: 10.1016/j.clnu.2022.05.007_bib22 article-title: Preserving healthy muscle during weight loss publication-title: Adv Nutr doi: 10.3945/an.116.014506 contributor: fullname: Cava – volume: 12 start-page: 3117 year: 2011 ident: 10.1016/j.clnu.2022.05.007_bib60 article-title: Inflammation, oxidative stress, and obesity publication-title: Int J Mol Sci doi: 10.3390/ijms12053117 contributor: fullname: Fernández-Sánchez – volume: 13 start-page: 423 year: 2015 ident: 10.1016/j.clnu.2022.05.007_bib62 article-title: Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies publication-title: Metab Syndr Relat Disord doi: 10.1089/met.2015.0095 contributor: fullname: Manna – volume: 93 start-page: 257 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib11 article-title: Obesity aggravates COVID-19: a systematic review and meta-analysis publication-title: J Med Virol doi: 10.1002/jmv.26237 contributor: fullname: Yang – volume: 112 start-page: 383 year: 2019 ident: 10.1016/j.clnu.2022.05.007_bib10 article-title: A proposed inflammatory score of circulating cytokines/adipokines associated with resistant hypertension, but dependent on obesity parameters publication-title: Arq Bras Cardiol contributor: fullname: Faria – volume: 32 start-page: 625 issue: 3 year: 2022 ident: 10.1016/j.clnu.2022.05.007_bib23 article-title: The impact of bariatric surgery on the muscle mass in patients with obesity: 2-year follow-up publication-title: Obes Surg doi: 10.1007/s11695-021-05815-x contributor: fullname: Martínez – volume: 31 start-page: 2352 year: 2015 ident: 10.1016/j.clnu.2022.05.007_bib7 article-title: Inflamación y obesidad (Lipoinflamación) publication-title: Nutr Hosp contributor: fullname: Izaola – volume: 11 start-page: 2368 year: 2019 ident: 10.1016/j.clnu.2022.05.007_bib18 article-title: Effect of a very-low-calorie ketogenic diet on circulating myokine levels compared with the effect of bariatric surgery or a low-calorie diet in patients with obesity publication-title: Nutrients doi: 10.3390/nu11102368 contributor: fullname: Sajoux – volume: 21 start-page: 263 year: 2015 ident: 10.1016/j.clnu.2022.05.007_bib34 article-title: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease publication-title: Nat Med doi: 10.1038/nm.3804 contributor: fullname: Youm – volume: 48 start-page: 341 year: 2009 ident: 10.1016/j.clnu.2022.05.007_bib41 article-title: Tachyphylaxis effects on postprandial oxidative stress and mitochondrial-related gene expression in overweight subjects after a period of energy restriction publication-title: Eur J Nutr doi: 10.1007/s00394-009-0019-9 contributor: fullname: Crujeiras – volume: 10 start-page: 435 year: 2007 ident: 10.1016/j.clnu.2022.05.007_bib63 article-title: Effect of short-term ketogenic diet on redox status of human blood publication-title: Rejuvenation Res doi: 10.1089/rej.2007.0540 contributor: fullname: Nazarewicz – volume: 21 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib72 article-title: Short-term physiological effects of a very low-calorie ketogenic diet: effects on adiponectin levels and inflammatory states publication-title: Int J Mol Sci doi: 10.3390/ijms21093228 contributor: fullname: Monda – volume: 12 start-page: 7637 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib27 article-title: Immunonutrition effects on coping with COVID-19 publication-title: Food Funct doi: 10.1039/D1FO01278A contributor: fullname: Dos Santos Ferreira – volume: 10 year: 2019 ident: 10.1016/j.clnu.2022.05.007_bib28 article-title: Clinical advances in immunonutrition and atherosclerosis: a review publication-title: Front Immunol doi: 10.3389/fimmu.2019.00837 contributor: fullname: Ruiz-León – volume: 19 start-page: 313 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib33 article-title: Ketone bodies: from enemy to friend and guardian angel publication-title: BMC Med doi: 10.1186/s12916-021-02185-0 contributor: fullname: Kolb – volume: 12 start-page: 287 year: 2016 ident: 10.1016/j.clnu.2022.05.007_bib49 article-title: Matrix metalloproteinases in exercise and obesity publication-title: Vasc Health Risk Manag doi: 10.2147/VHRM.S103877 contributor: fullname: Jaoude – volume: 12 start-page: 251 year: 2008 ident: 10.1016/j.clnu.2022.05.007_bib14 article-title: Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study publication-title: OMICS A J Integr Biol doi: 10.1089/omi.2008.0001 contributor: fullname: Crujeiras – volume: 11 year: 2019 ident: 10.1016/j.clnu.2022.05.007_bib46 article-title: Dysregulation of natural killer cells in obesity publication-title: Cancers contributor: fullname: O'Shea – volume: 13 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib53 article-title: Stress hyperglycemia and osteocalcin in COVID-19 critically ill patients on artificial nutrition publication-title: Nutrients doi: 10.3390/nu13093010 contributor: fullname: Arrieta – volume: 12 start-page: 72 issue: 1 year: 2019 ident: 10.1016/j.clnu.2022.05.007_bib25 article-title: DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se publication-title: BMC Med Genom doi: 10.1186/s12920-019-0522-7 contributor: fullname: Nicoletti – volume: 124 start-page: 3240 year: 2018 ident: 10.1016/j.clnu.2022.05.007_bib52 article-title: Cells, cytokines, chemokines, and cancer stress: a biobehavioral study of patients with chronic lymphocytic leukemia publication-title: Cancer doi: 10.1002/cncr.31538 contributor: fullname: Andersen – volume: 6 year: 2016 ident: 10.1016/j.clnu.2022.05.007_bib65 article-title: Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus publication-title: Nutr Diabetes doi: 10.1038/nutd.2016.36 contributor: fullname: Goday – volume: 8 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib8 article-title: Combining machine learning and metabolomics to identify weight gain biomarkers publication-title: Front Bioeng Biotechnol doi: 10.3389/fbioe.2020.00006 contributor: fullname: Dias-Audibert – volume: 54 start-page: 111 year: 2016 ident: 10.1016/j.clnu.2022.05.007_bib35 article-title: Effect of DHA supplementation in a very low-calorie ketogenic diet in the treatment of obesity: a randomized clinical trial publication-title: Endocrine doi: 10.1007/s12020-016-0964-z contributor: fullname: de Luis – volume: 10 start-page: 6515 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib56 article-title: Altered pathways in methylome and transcriptome longitudinal analysis of normal weight and bariatric surgery women publication-title: Sci Rep doi: 10.1038/s41598-020-60814-9 contributor: fullname: Nicoletti – volume: 15 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib9 article-title: Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk publication-title: PLoS One doi: 10.1371/journal.pone.0228633 contributor: fullname: Elisia – volume: 40 start-page: 514 year: 2016 ident: 10.1016/j.clnu.2022.05.007_bib5 article-title: Secreted factors derived from obese visceral adipose tissue regulate the expression of breast malignant transformation genes publication-title: Int J Obes doi: 10.1038/ijo.2015.208 contributor: fullname: Crujeiras – volume: 13 start-page: 217 year: 2017 ident: 10.1016/j.clnu.2022.05.007_bib50 article-title: Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2017.22 contributor: fullname: Croft – volume: 9 start-page: 1307 year: 2018 ident: 10.1016/j.clnu.2022.05.007_bib17 article-title: Physical exercise-induced myokines and muscle-adipose tissue crosstalk: a review of current knowledge and the implications for health and metabolic diseases publication-title: Front Physiol doi: 10.3389/fphys.2018.01307 contributor: fullname: Leal – start-page: 1 year: 2020 ident: 10.1016/j.clnu.2022.05.007_bib67 article-title: Could ketogenic diet “starve” cancer? Emerging evidence publication-title: Crit Rev Food Sci Nutr contributor: fullname: Barrea – volume: 45 start-page: 26 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib70 article-title: Ketogenic diet and cancer: fad or fabulous? publication-title: JPEN - J Parenter Enter Nutr doi: 10.1002/jpen.2226 contributor: fullname: Mundi – volume: 375 start-page: 794 year: 2016 ident: 10.1016/j.clnu.2022.05.007_bib4 article-title: Body fatness and cancer--viewpoint of the IARC working group publication-title: N Engl J Med doi: 10.1056/NEJMsr1606602 contributor: fullname: Lauby-Secretan – volume: 13 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib51 article-title: Serum levels of the cytokine TWEAK are associated with metabolic status in patients with prostate cancer and modulate cancer cell lipid metabolism in vitro publication-title: Cancers doi: 10.3390/cancers13184688 contributor: fullname: Altuna-Coy – volume: 62 start-page: 398 year: 2022 ident: 10.1016/j.clnu.2022.05.007_bib71 article-title: Very low-calorie ketogenic diet (VLCKD) in patients with psoriasis and obesity: an update for dermatologists and nutritionists publication-title: Crit Rev Food Sci Nutr doi: 10.1080/10408398.2020.1818053 contributor: fullname: Barrea – volume: 13 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib31 article-title: β-Hydroxybutyrate as an anti-aging metabolite publication-title: Nutrients doi: 10.3390/nu13103420 contributor: fullname: Wang – volume: 54 start-page: 681 year: 2016 ident: 10.1016/j.clnu.2022.05.007_bib37 article-title: Obesity treatment by very low-calorie-ketogenic diet at two years: reduction in visceral fat and on the burden of disease publication-title: Endocrine doi: 10.1007/s12020-016-1050-2 contributor: fullname: Moreno – volume: 13 start-page: 279 year: 2017 ident: 10.1016/j.clnu.2022.05.007_bib48 article-title: Examination of levels pentraxin-3, interleukin-6, and C-reactive protein in rat model acute and chronic exercise publication-title: J Exerc Rehabil doi: 10.12965/jer.1734920.490 contributor: fullname: Tunc-Ata – volume: 22 start-page: 1373 year: 2014 ident: 10.1016/j.clnu.2022.05.007_bib47 article-title: Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots and weight loss publication-title: Obesity doi: 10.1002/oby.20695 contributor: fullname: Witasp – volume: 13 issue: 4 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib26 article-title: Precision nutrition to activate thermogenesis as a complementary approach to target obesity and associated-metabolic-disorders publication-title: Cancers doi: 10.3390/cancers13040866 contributor: fullname: Reguero – volume: 16 start-page: 120 year: 2017 ident: 10.1016/j.clnu.2022.05.007_bib61 article-title: Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0604-9 contributor: fullname: Karam – volume: 14 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib66 article-title: Randomized clinical trial to evaluate the morphological changes in the adventitial vasa vasorum density and biological markers of endothelial dysfunction in subjects with moderate obesity undergoing a very low-calorie ketogenic diet publication-title: Nutrients doi: 10.3390/nu14010033 contributor: fullname: Sánchez – volume: 47 start-page: 793 year: 2014 ident: 10.1016/j.clnu.2022.05.007_bib36 article-title: Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity publication-title: Endocrine doi: 10.1007/s12020-014-0192-3 contributor: fullname: Moreno – volume: 40 start-page: 3959 year: 2021 ident: 10.1016/j.clnu.2022.05.007_bib21 article-title: Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity publication-title: Clin Nutr doi: 10.1016/j.clnu.2021.05.010 contributor: fullname: Crujeiras |
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| Title | Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight |
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