Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

Organoids are in vitro three-dimensional structures that can be grown from patient tissue. Head and neck cancer (HNC) is a collective term used for multiple tumor types including squamous cell carcinomas and salivary gland adenocarcinomas. Organoids were established from HNC patient tumor tissue and...

Full description

Saved in:

Bibliographic Details
Published in:	Med (New York, N.Y. : Online) Vol. 4; no. 5; p. 290
Main Authors:	Millen, Rosemary, De Kort, Willem W B, Koomen, Mandy, van Son, Gijs J F, Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P J, Geurts, Maarten H, Elias, Sjoerd G, van Es, Robert J J, de Bree, Remco, Devriese, Lot A, Willems, Stefan M, Kranenburg, Onno, Driehuis, Else, Clevers, Hans
Format:	Journal Article
Language:	English
Published:	United States 12-05-2023
Subjects:	Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomarkers - metabolism Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Humans Organoids - metabolism Organoids - pathology Protein-Arginine N-Methyltransferases - metabolism CRISPR Foundational research targeted therapy head and neck cancer organoids patient-derived models personalised medicine radiotherapy cancer 3D models
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!