The influence of 2 br-alpha-ergocryptine (CB-154) and apomorphine on induced prolactin secretion in the crab eating monkey (Macaca fascicularis)

• Published in: Endocrine research communications Vol. 2; no. 1; p. 95
• Main Authors: Gala, R R, Jaques, Jr, S
• Format: Journal Article
• Language: English
• Published: United States 1975
• Subjects: Animals; Apomorphine - pharmacology; Bromocriptine - pharmacology; Castration; Ergolines - pharmacology; Female; Humans; Macaca fascicularis; Ovary - physiology; Perphenazine - pharmacology; Prolactin - blood; Prolactin - immunology; Radioimmunoassay; Thyrotropin-Releasing Hormone - pharmacology; Time Factors
• ISSN: 0093-6391
• DOI: 10.3109/07435807509053841

The influence of apomorphine and 2 Br-alpha-ergocryptine (CB-154) on drug-induced prolactin secretion was examined in an intact and an ovariectomized monkey (Macaca fascicularis). Perphenazine administered iv at one mg/kg BW induced a rapid and marked increase in serum prolactin. Apomorphine at a concentration of 4 mg/kg BW administered prior to perphenazine delayed the perphenazine-induced prolactin rise. The iv administration of CB-154 at either 200 or 2000 mu-g/kg BW completely blocked the perphenazine response. Apomorphine injected before TRH suppressed the induced prolactin increase to this releasing hormone while CB-154, even at the very high dose, only partially blocked the TRH-induced prolactin rise. Serotonin injected iv at the level of 10 mg/kg BW induced a rapid and marked increase in serum prolactin and both apomorphine and CB-154 were able to block this response.