A Novel Compound from the Phenylsulfonylpiperazine Class: Evaluation of In Vitro Activity on Luminal Breast Cancer Cells

Breast cancer (BC) is the most common cancer in women, and is characterized by its histological and molecular heterogeneity. Luminal BC is an estrogen receptor-positive subtype, with varied clinical courses. Although BC patients are eligible for hormone therapy, both early and late relapses still oc...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 29; no. 18; p. 4471
Main Authors:	da Silva, Fernanda Cardoso, Martinho, Ana Clara Cassiano, Ferreira, Helen Soares Valença, Siqueira, Raoni Pais, Arruda, Vinicius Marques, Guerra, Joyce Ferreira da Costa, de Souza, Maria Laura Dos Reis, Landin, Emanuelly Silva, Rezende Júnior, Celso de Oliveira, de Araújo, Thaise Gonçalves
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 20-09-2024 MDPI
Subjects:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cells chemotherapy Cytotoxicity Development and progression Disease Drug Screening Assays, Antitumor Epithelial-Mesenchymal Transition - drug effects Ethylenediaminetetraacetic acid Female Humans MCF-7 Cells Medical prognosis Metastasis Nitrogen NMR Nuclear magnetic resonance phenylsulfonylpiperazine Piperazines - chemistry Piperazines - pharmacology Structure-Activity Relationship sulfonamides Tumors Canada Massachusetts breast cancer phenylsulfonylpiperazine sulfonamides chemotherapy cytotoxicity
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