Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae

The GPN proteins are a poorly characterized and deeply evolutionarily conserved family of three paralogous small GTPases, Gpn1, 2, and 3. The founding member, GPN1/NPA3/XAB1, is proposed to function in nuclear import of RNA polymerase II along with a recently described protein called Iwr1. Here we s...

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Bibliographic Details
Published in:	Genetics (Austin) Vol. 193; no. 3; pp. 853 - 864
Main Authors:	Minaker, Sean W, Filiatrault, Megan C, Ben-Aroya, Shay, Hieter, Philip, Stirling, Peter C
Format:	Journal Article
Language:	English
Published:	United States Genetics Society of America 01-03-2013
Subjects:	Active Transport, Cell Nucleus Alleles Biosynthesis Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell Nucleus - enzymology Cell Nucleus - metabolism Investigations Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Mutation Nuclear Localization Signals Polymers Protein Binding Protein Multimerization Protein Transport Ribonucleic acid RNA RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA Polymerase III - genetics RNA Polymerase III - metabolism Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Studies Transcription, Genetic
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