Isolated limb reperfusion with tumor necrosis factor and melphalan in patients with extremity melanoma after failure of isolated limb perfusion with chemotherapeutics

BACKGROUND This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS Seventeen patients with extremity mel...

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Bibliographic Details
Published in:	Cancer Vol. 80; no. 11; pp. 2084 - 2090
Main Authors:	Bartlett, David L., Ma, Grace, Alexander, H. Richard, Libutti, Steven K., Fraker, Douglas L.
Format:	Journal Article
Language:	English
Published:	New York John Wiley & Sons, Inc 01-12-1997 Wiley-Liss
Subjects:	Adult Aged Aged, 80 and over Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Arm Biological and medical sciences Dermatology Female Humans hyperthermia Hyperthermia, Induced in transit Leg limb perfusion Male medical oncology Medical sciences melanoma Melanoma - drug therapy melphalan Melphalan - administration & dosage metastases Middle Aged Perfusion - methods Retrospective Studies Skin Skin Neoplasms - drug therapy Treatment Outcome tumor necrosis factor Tumor Necrosis Factor-alpha - administration & dosage Tumors of the skin and soft tissue. Premalignant lesions Antineoplastic agent Human Relapse Cytokine Lower limb Malignant tumor Chemotherapy Reperfusion Tumor necrosis factor Melphalan Malignant melanoma End Negative therapeutic reaction
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