Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons

: Human membrane cofactor protein (CD46) controls complement activation and when expressed sufficiently as a transgene protects xenografts against complement‐mediated rejection, as shown here using non‐immunosuppressed baboons and heterotopic CD46 transgenic pig kidney xenografts. This report is of...

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Bibliographic Details
Published in:	Xenotransplantation (Københaven) Vol. 11; no. 2; pp. 171 - 183
Main Authors:	Loveland, Bruce E., Milland, Julie, Kyriakou, Peter, Thorley, Bruce R., Christiansen, Dale, Lanteri, Marc B., van Regensburg, Mark, Duffield, Maureen, French, Andrew J., Williams, Lindsay, Baker, Louise, Brandon, Malcolm R., Xing, Pei-Xiang, Kahn, Del, McKenzie, Ian F.C.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Munksgaard International Publishers 01-03-2004
Subjects:	Acute Disease Animals Animals, Genetically Modified Antibodies, Heterophile - blood Antigens, CD - genetics complement regulation Crosses, Genetic Disaccharides - blood Epitopes - blood Graft Rejection - immunology Graft Rejection - prevention & control human membrane cofactor protein Humans hyperacute rejection Immunosuppression Kidney Transplantation - immunology Kidney Transplantation - pathology Membrane Cofactor Protein Membrane Glycoproteins - genetics Mice Mice, Inbred C57BL Mice, Inbred Strains minigene Papio Swine transgenic Transplantation, Heterologous - immunology Transplantation, Heterologous - pathology xenotransplantation
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