Lysosomal cell death mechanisms in aging

• Published in: Ageing research reviews Vol. 32; pp. 150 - 168
• Main Authors: Gómez-Sintes, Raquel, Ledesma, María Dolores, Boya, Patricia
• Format: Journal Article
• Language: English
• Published: England 01-12-2016
• Subjects: Aging - physiology; Animals; Apoptosis - physiology; Autophagy - physiology; Cathepsins - metabolism; Cell Death - physiology; Humans; Internal Medicine; Lysosomes - physiology; Neurodegenerative Diseases - metabolism; Neurology; APP; TPEN; lipids; cluster of differentiation 3 receptor; biphosphinic palladacycle complex; DFO; 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine; mouse embryo fibroblasts; Hsp70; lysosomal cell death; CMA; heat shock protein 70; TTMl; DRAM; AIF; GCase; lysophosphatidylcholine; AD; NNN’N’-tetrakis (-)(2-pyridylmethyl- ethylenediamine; TRAIL; autophagy; Alzheimer’s disease; acid sphingomyelinase; GTSM; soluble N-ethylmaleimide attachment protein receptor proteins; Cu,Zn superoxide dismutase; PLA2; phosphofurin acidic cluster sorting protein-2; progressive myoclonic epilepsy type 1; glucocerebrosidase; low-density lipoproteins; apoptosis inducing factor; (-)-epigallocatechin-3- gallate; apolipoprotein E; human immunodeficiency virus; lipopolysaccharide; 3-methyladenine; concanamycin A; LPS; EPM1; LC3-associated phagocytosis; LSDs; ApoE; lysosomes; ASM; BMP; PtdIns(3,5)P2; Cys C; SOD; cathepsin; 6-hydroxydopamine; desferrioxamine; interleukin-1 beta; HIV; autophagosome-lysosome reformation; lysosomal storage disorders; 3-MA; LAP; MPTP; phosphatidic acid; aging; bis(monoacylglycero) phosphate; cystatin C; O-methyl-serine dodecylamide hydrochloride; bafilomycin A; ALR; Baf A; ALS; 6-OHDA; transcription factor EB; small interfering RNA; Leu-Leu methyl ester; amyotrophic lateral sclerosis; MSDH; phosphatidylinositol (3,5)biphosphate; Aβ; damage-regulated autophagy modulator; SNAREs; AMD; β-amyloid; MEFs; EGCG; N-acetylcystein; TFEB; IL-1β; LCD; SIRT1; MMP; PACS-2; BPC; ROS; mitochondrial membrane permeabilization; tumor necrosis factor α; RPE; age- dependent macular degeneration; lysosomal membrane permeabilization; chaperone- mediated autophagy; phopholipase A2; amyloid precursor protein; LDL; Leu-Leu-OMe; reactive oxygen species; thiosemicarbazone; TNF-related apoptosis-inducing ligand; retinal pigment epithelium; sirtuin 1; rd10; Con A; tetrathiomolibdate; siRNA; ATPase Type 13A2; retinal degeneration 10 mice; di-2-pyridylketone 4,4-dimethyl-3- thiosemicarbazone; LMP; NAC; PA; CD3; LysoPC; PD; TNF-α; ATP13A2; Parkinson’s disease; Dp44mT; Lysosomal membrane permeabilization; Cathepsin; Aging; Lysosomal cell death; Lysosomes; Lipids; Autophagy
• ISSN: 1568-1637; 1872-9649
• DOI: 10.1016/j.arr.2016.02.009

Highlights • Lysosomal cell death participates in physiological processes, aging, and disease. • Lysosomal membrane permeabilization plays a key role in lysosomal cell death. • Inducers and inhibitors of lysosomal cell death may be of therapeutic value.