Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A

Orexins (orexin-A and orexin-B) are hypothalamic peptides that are produced by the same precursor and are involved in sleep/wake control, which is mediated by two G protein-coupled receptor subtypes, OX1R and OX2R. Ulcerative colitis (UC) is an inflammatory bowel disease, (IBD) which is characterize...

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Published in:	Biochimica et biophysica acta. Molecular basis of disease Vol. 1864; no. 11; pp. 3618 - 3628
Main Authors:	Messal, N., Fernandez, N., Dayot, S., Gratio, V., Nicole, P., Prochasson, C., Chantret, I., LeGuilloux, G., Jarry, A., Couvelard, A., Tréton, X., Voisin, T., Ogier-Denis, E., Couvineau, A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-11-2018 Elsevier
Subjects:	Adult Animals Cancer Cell Line Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - immunology Colitis, Ulcerative - pathology Cytokines - immunology Cytokines - metabolism Dextran Sulfate - toxicity Disease Models, Animal Down-Regulation Ectopic Gene Expression Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology Female GPCR Humans Inflammation Inflammatory bowel disease Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - pathology Life Sciences Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Middle Aged Neuropeptide NF-kappa B - immunology NF-kappa B - metabolism Orexin Receptor Antagonists - pharmacology Orexin Receptors - genetics Orexin Receptors - metabolism Orexins Orexins - pharmacology Orexins - therapeutic use Phenylurea Compounds - pharmacology Retrospective Studies Signal Transduction - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Ulcerative colitis Young Adult Inflammatory bowel disease GPCR Inflammation Orexins Neuropeptide Ulcerative colitis
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