Lymphoma during pregnancy in Japan: a multicenter retrospective cohort study

• Published in: International journal of hematology Vol. 115; no. 3; pp. 382 - 390
• Main Authors: Onishi, Chie, Nishikori, Momoko, Yakushijin, Kimikazu, Kurahashi, Shingo, Nakazawa, Hideyuki, Takamatsu, Yasushi, Hashimoto, Yoshinori, Tatetsu, Hiro, Yuichiro Nawa, Yoshida, Masahiro, Kobayashi, Tsutomu, Oyake, Tatsuo, Yano, Shingo, Oride, Aki, Suzuki, Ritsuro
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01-03-2022; Springer Nature B.V
• Subjects: Adult; Chemotherapy; Cohort analysis; Female; Fetuses; Follow-Up Studies; Hematology; Hodgkin Disease - drug therapy; Hodgkin Disease - epidemiology; Hodgkin Disease - mortality; Humans; Incidence; Japan - epidemiology; Lymphadenopathy; Lymphadenopathy - epidemiology; Lymphoma; Lymphoma, Non-Hodgkin - drug therapy; Lymphoma, Non-Hodgkin - epidemiology; Lymphoma, Non-Hodgkin - mortality; Medicine; Medicine & Public Health; Miscarriage; Non-Hodgkin's lymphoma; Oncology; Original Article; Patients; Pneumonia, Pneumocystis - epidemiology; Pregnancy; Pregnancy Complications, Infectious - epidemiology; Pregnancy Complications, Neoplastic - drug therapy; Pregnancy Complications, Neoplastic - epidemiology; Pregnancy Complications, Neoplastic - mortality; Pregnancy Outcome; Premature birth; Retrospective Studies; Survival; Survival Rate; Young Adult; Japan; Pregnancy; Extranodal sites; pneumonia; Lymphoma; Pneumocystis jiroveci pneumonia
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-021-03281-w

Objective
This study was conducted to characterize lymphoma occurring during pregnancy and to investigate the outcomes of the patients and the fetuses.
Methods
Clinical data were gathered retrospectively from 29 patients at 13 participating institutions, and data from 28 eligible patients were analyzed.
Results
Six (21%) patients had Hodgkin lymphoma (HL) and 22 (79%) patients had non-Hodgkin lymphoma (NHL). All patients with HL presented with lymphadenopathy, but 15 (68%) of the 22 patients with NHL presented with extranodal sites only. At the median follow-up period of 1325 (range 6–4461) days, the 5-year overall survival rate was 63% for patients with NHL and 100% for patients with HL. Three of the 13 patients who received chemotherapy during pregnancy (23%) developed Pneumocystis jiroveci pneumonia (PCP). There was 1 intrauterine fetal death, 1 spontaneous abortion in the first trimester, and 15 (54%) preterm births.
Conclusion
This study showed a higher proportion of NHL than HL during pregnancy in Japan, which was inconsistent with the proportions observed in Western countries. The high incidence of maternal PCP and preterm birth suggested the need for improvements in our management of lymphoma during pregnancy.