Cytosine Arabinoside With Daunorubicin or Adriamycin for Therapy of Acute Myelocytic Leukemia: A CALGB Study
A randomized comparison of the relative efficacy and toxicity of daunorubicin (DNR) at 30 or 45 mg/sq m or adriamycin (ADM) at 30 mg/sq m, given on the first 3 days of a 7-day continuous infusion of cytosine arabinoside (ara-C) at 100 mg/sq m/day. shows the outcome to be dependent on anthracycline,...
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| Published in: | Blood Vol. 60; no. 2; pp. 454 - 462 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
01-08-1982
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| Online Access: | Get full text |
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| Abstract | A randomized comparison of the relative efficacy and toxicity of daunorubicin (DNR) at 30 or 45 mg/sq m or adriamycin (ADM) at 30 mg/sq m, given on the first 3 days of a 7-day continuous infusion of cytosine arabinoside (ara-C) at 100 mg/sq m/day. shows the outcome to be dependent on anthracycline, dose, and patient age. DNR 45 is significantly better than DNR 30 or ADM 30 for inducing complete remissions (CR) in patients younger than 60 yr, (72%. 59%. 58% CRs. respectively). DNR 30 is better than DNR 45 or ADM 30 for inducing CR in patients older than 60 yr (47%, 31 %, 35%. respectively). There was a corresponding shift in the induction mortality for the age. dose, and anthracycline groups. Adriamycin was significantly more toxic to the gastrointestinal tract than daunorubicin. The duration of complete remission, with cyclic courses of maintenance therapy, was independent of the patient's age. the dose, or choice of anthracycline used in induction, and of whether the maintenance courses were given every 4 wk or every 8 wk. |
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| AbstractList | A randomized comparison of the relative efficacy and toxicity of daunorubicin (DNR) at 30 or 45 mg/sq m or adriamycin (ADM) at 30 mg/sq m, given on the first 3 days of a 7-day continuous infusion of cytosine arabinoside (ara-C) at 100 mg/sq m/day, shows the outcome to be dependent on anthracycline, dose, and patient age. DNR 45 is significantly better than DNR 30 or ADM 30 for inducing complete remissions (CR) in patients younger than 60 yr, (72%, 59%, 58% CRs, respectively). DNR 30 is better than DNR 45 or ADM 30 for inducing CR in patients older than 60 yr (47%, 31%, 35%, respectively). There was a corresponding shift in the induction mortality for the age, dose, and anthracycline groups. Adriamycin was significantly more toxic to the gastrointestinal tract than daunorubicin. The duration of complete remission, with cyclic courses of maintenance therapy, was independent of the patient's age, the dose, or choice of anthracycline used in induction, and of whether the maintenance courses were given every 4 wk or every 8 wk. |
| Author | Leone, Louis Cooper, M.Robert Wiernik, Peter Glidewell, Oliver Falkson, Geoffrey Hutchison, J.Lawrence Frelick, Robert Holland, James F. Berenberg, Jeffrey Cornell, Cornelius Henry, Patrick Nissen, Nis Raich, Peter Dosik, Harvey Haurani, Farid Steinberg, David Ellison, Rose Ruth Yates, Jerome Green, Mark Levy, Robert Silver, Richard T. James, G.Watson Gottlieb, Arlan Henderson, Edward Hoagland, Clark |
| Author_xml | – sequence: 1 givenname: Jerome surname: Yates fullname: Yates, Jerome – sequence: 2 givenname: Oliver surname: Glidewell fullname: Glidewell, Oliver – sequence: 3 givenname: Peter surname: Wiernik fullname: Wiernik, Peter – sequence: 4 givenname: M.Robert surname: Cooper fullname: Cooper, M.Robert – sequence: 5 givenname: David surname: Steinberg fullname: Steinberg, David – sequence: 6 givenname: Harvey surname: Dosik fullname: Dosik, Harvey – sequence: 7 givenname: Robert surname: Levy fullname: Levy, Robert – sequence: 8 givenname: Clark surname: Hoagland fullname: Hoagland, Clark – sequence: 9 givenname: Patrick surname: Henry fullname: Henry, Patrick – sequence: 10 givenname: Arlan surname: Gottlieb fullname: Gottlieb, Arlan – sequence: 11 givenname: Cornelius surname: Cornell fullname: Cornell, Cornelius – sequence: 12 givenname: Jeffrey surname: Berenberg fullname: Berenberg, Jeffrey – sequence: 13 givenname: J.Lawrence surname: Hutchison fullname: Hutchison, J.Lawrence – sequence: 14 givenname: Peter surname: Raich fullname: Raich, Peter – sequence: 15 givenname: Nis surname: Nissen fullname: Nissen, Nis – sequence: 16 givenname: Rose Ruth surname: Ellison fullname: Ellison, Rose Ruth – sequence: 17 givenname: Robert surname: Frelick fullname: Frelick, Robert – sequence: 18 givenname: G.Watson surname: James fullname: James, G.Watson – sequence: 19 givenname: Geoffrey surname: Falkson fullname: Falkson, Geoffrey – sequence: 20 givenname: Richard T. surname: Silver fullname: Silver, Richard T. – sequence: 21 givenname: Farid surname: Haurani fullname: Haurani, Farid – sequence: 22 givenname: Mark surname: Green fullname: Green, Mark – sequence: 23 givenname: Edward surname: Henderson fullname: Henderson, Edward – sequence: 24 givenname: Louis surname: Leone fullname: Leone, Louis – sequence: 25 givenname: James F. surname: Holland fullname: Holland, James F. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6953986$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 1982 American Society of Hematology |
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| DOI | 10.1182/blood.V60.2.454.454 |
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| Discipline | Medicine Chemistry Biology Anatomy & Physiology |
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| PublicationTitle | Blood |
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| Snippet | A randomized comparison of the relative efficacy and toxicity of daunorubicin (DNR) at 30 or 45 mg/sq m or adriamycin (ADM) at 30 mg/sq m, given on the first 3... |
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| SubjectTerms | Adolescent Adult Age Factors Aged Child Child, Preschool Colitis, Ulcerative - chemically induced Cytarabine - adverse effects Cytarabine - therapeutic use Daunorubicin - adverse effects Daunorubicin - therapeutic use Dose-Response Relationship, Drug Doxorubicin - adverse effects Doxorubicin - therapeutic use Drug Administration Schedule Drug Therapy, Combination Female Humans Infant Leukemia, Myeloid, Acute - drug therapy Male Middle Aged Stomatitis - chemically induced |
| Title | Cytosine Arabinoside With Daunorubicin or Adriamycin for Therapy of Acute Myelocytic Leukemia: A CALGB Study |
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