Harnessing IgG Fc glycosylation for clinical benefit

The effector activity of IgG antibodies is regulated at several levels, including IgG subclass, modifications of the Fc glycan, and the distribution of Type I and II Fcγ receptors (FcγR) on effector cells. Here, we explore how Fc glycosylation, particularly sialylation and fucosylation, tunes cellul...

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Bibliographic Details
Published in:	Current opinion in immunology Vol. 77; p. 102231
Main Authors:	Archer, Eva J, Gonzalez, Joseph C, Ghosh, Debopam, Mellins, Elizabeth D, Wang, Taia T
Format:	Journal Article
Language:	English
Published:	England 01-08-2022
Subjects:	Antigen-Antibody Complex - metabolism Glycosylation Humans Immunoglobulin Fc Fragments Immunoglobulin G - metabolism Polysaccharides Receptors, IgG
Online Access:	Get full text
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Summary:	The effector activity of IgG antibodies is regulated at several levels, including IgG subclass, modifications of the Fc glycan, and the distribution of Type I and II Fcγ receptors (FcγR) on effector cells. Here, we explore how Fc glycosylation, particularly sialylation and fucosylation, tunes cellular responses to immune complexes. We review the current understanding of the pathways and mechanisms underlying this biology, address FcγR in antigen presentation, and discuss aspects of the clinical understanding of Fc glycans in therapies and disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2022.102231