A warfarin-piroxicam drug interaction

A piroxicam-warfarin interaction is presented with a discussion of the possible mechanism of action. A 60-year-old white male on warfarin therapy for recurrent pulmonary embolism and deep venous thrombophlebitis showed a decrease in his previously therapeutic and stable prothrombin time when piroxic...

Full description

Saved in:

Bibliographic Details
Published in:	Drug intelligence & clinical pharmacy Vol. 19; no. 7-8; p. 556
Main Authors:	Rhodes, R S, Rhodes, P J, Klein, C, Sintek, C D
Format:	Journal Article
Language:	English
Published:	United States 01-07-1985
Subjects:	Drug Interactions Humans Male Middle Aged Piroxicam Prothrombin Time Pulmonary Embolism - blood Thiazines - adverse effects Thrombophlebitis - blood Warfarin - adverse effects
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A piroxicam-warfarin interaction is presented with a discussion of the possible mechanism of action. A 60-year-old white male on warfarin therapy for recurrent pulmonary embolism and deep venous thrombophlebitis showed a decrease in his previously therapeutic and stable prothrombin time when piroxicam was discontinued from his drug regimen. On two rechallenges over a ten-month period, his prothrombin times showed consistent and clinically significant fluctuations as piroxicam was added and deleted from his drug regimen.
ISSN:	0012-6578
DOI:	10.1177/106002808501900711