Determination of the Immunoglobulin E Postoperative Variation as a Measure of Surgical Injury

• Published in: World journal of surgery Vol. 25; no. 5; pp. 585 - 591
• Main Authors: Navarro‐Zorraquino, Marta, Lozano, Ricardo, Deus, Javier, Pastor, Cristina, Larrad, Luis, Tejero, Eloy, Román, Javier, Palacios, María J., Torcal, Javier, Salinas, José C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer‐Verlag 01-05-2001; Springer; Springer Nature B.V
• Subjects: Adult; Antigens, CD - blood; Biliary Tract Surgical Procedures; Biological and medical sciences; Cardiovascular Surgical Procedures; CD19 Increase; Cell Pathway; Early Postoperative Period; Female; Humans; Immunoglobulin E - blood; Immunoglobulins - blood; Interleukins - blood; Male; Medical sciences; Middle Aged; Miscellaneous; Postoperative Period; Postoperative Variation; Predominant Activation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Thoracic Surgical Procedures; Vascular Surgical Procedures; Human; Postoperative; Type; Treatment; Surgery; IgE; Variations; Complication; Duration; Determination; Operation; Trauma
• ISSN: 0364-2313; 1432-2323
• DOI: 10.1007/s002680020089

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The aim of this study was to ascertain postoperative changes in immunoglobulin E (IgE) in patients undergoing different types of surgery and the possible correlation with the duration and type of surgery. Evidence suggests that surgery induces a predominant activation pattern through the T‐helper‐2 (Th2) cell pathway, increasing interleukins (IL‐4, IL‐5, IL‐10, IL‐13), inhibiting Th1 cell activation, and promoting B and Th2 cell activation. IgE production may indicate predominant Th2 pathway activation and may be a more persistent and easily measurable postoperative marker than IL‐6 for measuring surgical trauma. Altogether, 180 patients undergoing different types of surgery for nonneoplastic and nonparasitic diseases were studied. All patients received the same type of anesthesia. Before surgery and on the first (1PO) and 7th (7PO) postoperative days we determined in peripheral blood the CD3, CD4, CD8, CD16, and CD19 cell percentages; IL‐1, IL‐2, IL‐4, IL‐6, and tumor necrosis factor (TNF) levels; and the IgA, IgG, IgM, total IgE, C3, C4, and CIC levels. On 1PO, all variables decreased except IgE, IL‐1, IL‐2, IL‐4, IL‐6, CIC, and CD19. Only IgE, IL‐6, and CD19 increases showed a significantly statistical (ss) difference regarding preoperative values (0.01, 0.05, 0.001, respectively). Relations between the IL‐4 and IgE increases (p < 0.01) and between the IgG decrease and IgE increase (p < 0.001) were found. On 7PO, only IgE was increased (p < 0.001). The IgE increase correlated with surgical trauma intensity (p < 0.05). We concluded that IgE increases during the early postoperative period, correlating with surgical injury intensity. The increase in the IgE level may be detected 24 hours after surgery and during the first 7 postoperative days depending on the type of surgery.