ADMA and NOS regulation in chronic renal disease: beyond the old rivalry for l-arginine
Chronic kidney disease is associated with increased levels of assymetric N(G),N(G)-dimethylarginine (ADMA), which is predictive of increased mortality and cardiovascular disease. ADMA induces endothelial dysfunction through competitive inhibition of the endothelial nitric oxide (eNOS) substrate L-ar...
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| Published in: | Kidney international Vol. 81; no. 8; p. 722 |
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| Format: | Journal Article |
| Language: | English |
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01-04-2012
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| Abstract | Chronic kidney disease is associated with increased levels of assymetric N(G),N(G)-dimethylarginine (ADMA), which is predictive of increased mortality and cardiovascular disease. ADMA induces endothelial dysfunction through competitive inhibition of the endothelial nitric oxide (eNOS) substrate L-arginine. Kajimoto et al. show that ADMA may also reduce nitric oxide production via decreased eNOS phosphorylation; this effect is mediated by the MAPK pathway and can be reversed in vivo by increased catabolism of ADMA through dimethylarginine dimethylaminohydrolase-1 overexpression. |
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| AbstractList | Chronic kidney disease is associated with increased levels of assymetric N(G),N(G)-dimethylarginine (ADMA), which is predictive of increased mortality and cardiovascular disease. ADMA induces endothelial dysfunction through competitive inhibition of the endothelial nitric oxide (eNOS) substrate L-arginine. Kajimoto et al. show that ADMA may also reduce nitric oxide production via decreased eNOS phosphorylation; this effect is mediated by the MAPK pathway and can be reversed in vivo by increased catabolism of ADMA through dimethylarginine dimethylaminohydrolase-1 overexpression. |
| Author | Dobrian, Anca D |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22460653$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1155_2020_5070415 crossref_primary_10_1371_journal_pone_0166492 crossref_primary_10_1038_s41598_021_96815_5 crossref_primary_10_20473_bhsj_v1i1_8226 crossref_primary_10_33549_physiolres_934420 crossref_primary_10_1007_s10157_012_0689_0 crossref_primary_10_3390_antiox9080752 crossref_primary_10_3390_ijms130911288 |
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| SubjectTerms | Animals Arginine - analogs & derivatives Arginine - blood Humans Male Nitric Oxide Synthase Type III - antagonists & inhibitors Renal Insufficiency, Chronic - physiopathology |
| Title | ADMA and NOS regulation in chronic renal disease: beyond the old rivalry for l-arginine |
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