Usefulness of a slow nutrient drinking test for evaluating gastric perception and accommodation

• Published in: Digestion Vol. 84; no. 4; p. 253
• Main Authors: Iida, Akihito, Konagaya, Toshihiro, Kaneko, Hiroshi, Funaki, Yasushi, Kanazawa, Tamotsu, Tokudome, Kentaro, Hijikata, Yasutaka, Masui, Ryuta, Ogasawara, Naotaka, Sasaki, Makoto, Yoneda, Masashi, Kasugai, Kunio
• Format: Journal Article
• Language: English
• Published: Switzerland 01-01-2011
• Subjects: Adult; Benzamides - pharmacology; Catheterization; Cross-Over Studies; Double-Blind Method; Drinking - physiology; Humans; Male; Middle Aged; Morpholines - pharmacology; Postprandial Period; Pressure; Satiation - drug effects; Satiation - physiology; Sensation - drug effects; Sensation - physiology; Serotonin Receptor Agonists - pharmacology; Stomach - drug effects; Stomach - physiology
• ISSN: 1421-9867
• DOI: 10.1159/000330843

An implication of the drinking test for gastric function is controversial. We evaluated the usefulness of a nutrient drinking test for examining gastric function by comparing it with a gastric barostat study.
We investigated perceived pressure of an intragastric bag with stepwise distension and postprandial peak gastric volume (accommodation volume) with a consistent pressure after drinking a liquid meal (200 ml, 300 kcal) in 18 volunteers. Drinking a similar liquid meal on a different day at a continual rate of 15 ml/min was performed to score satiety and bloated sensations at 5-min intervals. An additional 10 volunteers performed the drinking test before and after administration of mosapride citrate or a placebo in a double-blind crossover study.
Pressure to induce severe discomfort correlated positively with maximum satiety volume in the drinking test (r = 0.60, p = 0.02). Accommodation volume in the barostat study showed a significant correlation (r = 0.59, p = 0.03) with threshold volume to induce bloating in the drinking test. Mosapride tended to increase the volume inducing the first bloated sensation as compared to the placebo.
The present drinking test may be useful for evaluating the threshold to induce severe discomfort and accommodation volume.