Physical chemical properties of oral drug candidates in the discovery and exploratory development settings

The advent of automated in vitro screening of hundreds of thousands of compounds has introduced biases into the drug discovery process that have significant implications for subsequent drug development. Screening biases that impact oral absorption adversely are discussed, and approaches are suggeste...

Full description

Saved in:

Bibliographic Details
Published in:	Pharmaceutical Science & Technology Today Vol. 1; no. 9; pp. 387 - 393
Main Author:	Curatolo, William
Format:	Book Review Journal Article
Language:	English
Published:	Elsevier B.V 01-12-1998
Subjects:	absorption bioavailability drug development drug discovery intestinal permeability maximum absorbable dose medicinal chemistry oral absorption solubility intestinal permeability maximum absorbable dose drug discovery absorption bioavailability drug development solubility medicinal chemistry oral absorption
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The advent of automated in vitro screening of hundreds of thousands of compounds has introduced biases into the drug discovery process that have significant implications for subsequent drug development. Screening biases that impact oral absorption adversely are discussed, and approaches are suggested for the prediction, assessment and communication of absorption-related physical chemical properties in drug discovery and exploratory development.
ISSN:	1461-5347
DOI:	10.1016/S1461-5347(98)00097-2