Pilot study to assess toxicity and pharmacokinetics of docetaxel in patients with metastatic breast cancer and impaired liver function secondary to hepatic metastases

Background:Limited clinical data are available regarding the safety of docetaxel in metastatic breast cancer patients with liver dysfunction. Methods:Eligible patients had breast cancer with impaired liver function secondary to hepatic metastases and were candidates for docetaxel therapy. They were...

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Bibliographic Details
Published in:	Journal of oncology pharmacy practice Vol. 20; no. 2; pp. 120 - 129
Main Authors:	Eckmann, Karen, Michaud, Laura B, Rivera, Edgardo, Madden, Timothy L, Esparza-Guerra, Laura, Kawedia, Jitesh, Booser, Daniel J, Green, Marjorie C, Hortobagyi, Gabriel N, Valero, Vicente
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-04-2014 Sage Publications Ltd
Subjects:	Adult Aged Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Chemotherapy Docetaxel Female Humans Kinetics Liver Liver - drug effects Liver - pathology Liver Diseases - drug therapy Liver Neoplasms - drug therapy Liver Neoplasms - pathology Liver Neoplasms - secondary Male Metastasis Middle Aged Pharmacology Pilot Projects Taxoids - adverse effects Taxoids - pharmacokinetics Toxicity liver impairment chemotherapy Docetaxel metastatic breast cancer taxanes hepatic dysfunction
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