Interaction Modes between N7-Quarternized Guanine and Cytosine-Containing Dipeptides

7-Methyl-9-ethyl-guanine (7mG) was titrated by eleven cytosine-containing dipeptides (C-Xxx) monitoring the chemical shift of H8 proton. Amino acids incorporated to C-Xxx were related to the molecular ratio and association constant of the complex. In the Eadie-Hoffstee plots, the dipeptides of which...

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Bibliographic Details
Published in:	Chemistry letters Vol. 31; no. 11; pp. 1136 - 1137
Main Authors:	Asano, Akiko, Minoura, Katsuhiko, Ishida, Toshimasa, Tarui, Mariko, Doi, Mitsunobu
Format:	Journal Article
Language:	English
Published:	Tokyo The Chemical Society of Japan 2002 Chemical Society of Japan
Online Access:	Get full text
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Summary:	7-Methyl-9-ethyl-guanine (7mG) was titrated by eleven cytosine-containing dipeptides (C-Xxx) monitoring the chemical shift of H8 proton. Amino acids incorporated to C-Xxx were related to the molecular ratio and association constant of the complex. In the Eadie-Hoffstee plots, the dipeptides of which side chains could form hydrogen bonds showed two phases. The highest association constant was observed for C-Asn, and its level was 20 times greater than that of C-Trp.
ISSN:	0366-7022 1348-0715
DOI:	10.1246/cl.2002.1136