Effects of leucine methylester on guinea-pig atria

Superfusion of guinea-pig atria with 10 mM l-leucine methylester leads to a mechanical arrest and to an increase in protein outflow. Homogenate of atria exhibits a decrease in the sedimentability of phosphatase acid activity as compared to control. Morphological studies reveal that leucine methylest...

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Bibliographic Details
Published in:	Acta pharmacologica et toxicologica Vol. 57; no. 2; p. 141
Main Authors:	Franconi, F, Bennardini, F, Stendardi, I, Matucci, R, Dini, G, Giotti, A
Format:	Journal Article
Language:	English
Published:	Denmark 01-08-1985
Subjects:	Acid Phosphatase - metabolism Animals Guinea Pigs Heart - drug effects Heart Rate - drug effects In Vitro Techniques Leucine - analogs & derivatives Leucine - pharmacology Lysosomes - drug effects Male Mitochondria, Heart - drug effects Proteins - metabolism
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Summary:	Superfusion of guinea-pig atria with 10 mM l-leucine methylester leads to a mechanical arrest and to an increase in protein outflow. Homogenate of atria exhibits a decrease in the sedimentability of phosphatase acid activity as compared to control. Morphological studies reveal that leucine methylester causes not only a lysosomal swelling but also a disruption of myofibrils and slight mitochondrial damage.
ISSN:	0001-6683
DOI:	10.1111/j.1600-0773.1985.tb00022.x