Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves

A tissue cage model of inflammation in calves was used to determine the pharmacokinetic and pharmacodynamic properties of individual carprofen enantiomers, following the administration of the racemate. RS(±) carprofen was administered subcutaneously both alone and in combination with intramuscularly...

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Bibliographic Details
Published in:	Journal of veterinary pharmacology and therapeutics Vol. 36; no. 4; pp. 320 - 328
Main Authors:	Brentnall, C., Cheng, Z., Mckellar, Q. A., Lees, P.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-08-2013
Subjects:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Area Under Curve Carbazoles - administration & dosage Carbazoles - blood Carbazoles - pharmacokinetics Cattle - blood Cattle - metabolism Cross-Over Studies Diffusion Chambers, Culture - veterinary Dinoprostone - antagonists & inhibitors Drug Interactions Half-Life Injections, Intramuscular - veterinary Injections, Subcutaneous - veterinary Male Oxytetracycline - administration & dosage Oxytetracycline - blood Oxytetracycline - pharmacology Thromboxane B2 - antagonists & inhibitors
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