Functions and mechanisms of retrograde neurotrophin signalling

• Published in: Nature reviews. Neuroscience Vol. 6; no. 8; pp. 615 - 625
• Main Authors: Ginty, David D, Zweifel, Larry S, Kuruvilla, Rejji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01-08-2005
• Subjects: Ablation; Animals; Biological and medical sciences; Brain-derived neurotrophic factor; Cell culture; Cell death; Fundamental and applied biological sciences. Psychology; General aspects. Models. Methods; Glaucoma and intraocular pressure; Growth factors; Humans; Kinases; Medical sciences; Nerve Growth Factors - physiology; Nervous System Physiological Phenomena; Neurons - physiology; Neurosciences; Ophthalmology; Proteins; Signal transduction; Signal Transduction - physiology; Vertebrates: nervous system and sense organs; United States > US; Maryland; Baltimore Maryland; Neurotrophin; Program; Synaptogenesis; Growth; Cell death; Innervation; Retrograde; Axon; Review; Distance; Dendrite; Biological receptor
• ISSN: 1471-003X; 1471-0048; 1469-3178
• DOI: 10.1038/nrn1727

Neuronal connections are established and refined through a series of developmental programs that involve axon and dendrite specification, process growth, target innervation, cell death and synaptogenesis. Many of these developmental events are regulated by target-derived neurotrophins and their receptors, which signal retrogradely over long distances from distal-most axons to neuronal cell bodies. Recent work has established many of the cellular and molecular events that underlie retrograde signalling and the importance of these events for both development and maintenance of proper neural connectivity.