Placing Sites on the Edge of Planar Silicon Microelectrodes Enhances Chronic Recording Functionality

• Published in: IEEE transactions on biomedical engineering Vol. 65; no. 6; pp. 1245 - 1255
• Main Authors: Lee, Heui Chang, Gaire, Janak, Roysam, Badrinath, Otto, Kevin J.
• Format: Journal Article
• Language: English
• Published: United States IEEE 01-06-2018; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Animals; Biological tissue response; Cerebral Cortex - physiology; chronic neural implant; Electrodes, Implanted; Electronic devices; Histology; impedance spectroscopy; Male; Microelectrodes; Neural prostheses; Neurophysiological Monitoring - instrumentation; Neurophysiological Monitoring - methods; Noise levels; Performance evaluation; planar silicon microelectrodes; Rats; Rats, Long-Evans; Recording; Signal Processing, Computer-Assisted; Signal to noise ratio; Silicon; Silicon - chemistry; Silicon substrates; single unit recording; Site location; Substrates; Surgery
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/TBME.2017.2715811

Objective: This study aims to identify the impact of using edge sites over center sites on a planar silicon microelectrode array. Methods: We used custom-designed, silicon-substrate multisite microelectrode arrays with sites on the center, edge, and tip. We compared their single unit recording capability, noise level, impedance, and histology to identify the differences between each site location. Wide and narrow devices were used to evaluate if the differences are consistent and meet theoretical expectations. Results: On the wide device, significantly more number of edge sites were functional than center sites over the course of 8 weeks with generally higher signal-to-noise amplitude ratio. On the narrow device, edge sites also performed generally better than center sites, but the differences were not significant and smaller than wide devices. The data from the tip sites were inconclusive. Conclusion: Edge sites outperformed center sites in terms of single unit recording capability. This benefit decreased as the device gets narrower and the distance to center sites decreases. Significance: We showed that a simple alteration to the site placement can greatly enhance the functionality of silicon microelectrodes. This study promotes the idea that not only the substrate but also the site architecture needs attention to lengthen the lifetime of neural implants.