Molecular and Cytogenetic Studies in a Child with Burkitt Lymphoma and Ataxia-Telangiectasia Syndrome Harboring MYC Overexpression and Partial Trisomy 8

Dear Editor, Burkitt lymphoma/leukemia (BL/L) was the first neoplasia associated with rearrangement in MYC that is the molecular hallmark of this disease. Particularly, immunoglobulin genes are associated with MYC in BL/L, where the juxtaposition with heavy chain locus (14q32) or light chain loci (2...

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Bibliographic Details
Published in:	Annals of laboratory medicine Vol. 38; no. 1; pp. 63 - 66
Main Authors:	De Souza, Mariana T, Vera-Lozada, Gabriela, Othman, Moneeb, Marques-Salles, Teresinha J, Pinto, Luciana W, da Rocha, Moisés M, Rouxinol, Soraia, Liehr, Thomas, Ribeiro, Raul C, Hassan, Rocio, Silva, Maria Luiza M
Format:	Journal Article
Language:	English
Published:	Korea (South) The Korean Society for Laboratory Medicine 01-01-2018 대한진단검사의학회
Subjects:	Ataxia Telangiectasia - complications Ataxia Telangiectasia - diagnosis Ataxia Telangiectasia - genetics Burkitt Lymphoma - complications Burkitt Lymphoma - diagnosis Burkitt Lymphoma - genetics Child Chromosomes, Human, Pair 8 Humans In Situ Hybridization, Fluorescence Karyotype Letter to the Editor Male Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Translocation, Genetic Trisomy 병리학
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Summary:	Dear Editor, Burkitt lymphoma/leukemia (BL/L) was the first neoplasia associated with rearrangement in MYC that is the molecular hallmark of this disease. Particularly, immunoglobulin genes are associated with MYC in BL/L, where the juxtaposition with heavy chain locus (14q32) or light chain loci (2p12 and 22q11) leads to MYC overexpression, which is believed to play a central role in BL/L pathogenesis KCI Citation Count: 0
ISSN:	2234-3806 2234-3814
DOI:	10.3343/alm.2018.38.1.63