Liver X receptors in immune cell function in humans

The liver X receptors (LXRs), LXRα and LXRβ, are transcription factors with well-established roles in the regulation of lipid metabolism and cholesterol homeostasis. In addition, LXRs influence innate and adaptive immunity, including responses to inflammatory stimuli, proliferation and differentiati...

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Bibliographic Details
Published in:	Biochemical Society transactions Vol. 43; no. 4; p. 752
Main Authors:	Waddington, Kirsty E, Jury, Elizabeth C, Pineda-Torra, Inés
Format:	Journal Article
Language:	English
Published:	England 01-08-2015
Subjects:	Adaptive Immunity Animals Homeostasis Humans Immunity, Innate Lipid Metabolism Liver X Receptors Orphan Nuclear Receptors - metabolism Protein Isoforms - metabolism lipid rafts cholesterol innate immunity liver X receptors (LXRs) gene regulation adaptive immunity
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Summary:	The liver X receptors (LXRs), LXRα and LXRβ, are transcription factors with well-established roles in the regulation of lipid metabolism and cholesterol homeostasis. In addition, LXRs influence innate and adaptive immunity, including responses to inflammatory stimuli, proliferation and differentiation, migration, apoptosis and survival. However, the majority of work describing the role of LXRs in immune cells has been carried out in mouse models, and there are a number of known species-specific differences concerning LXR function. Here we review what is known about the role of LXRs in human immune cells, demonstrating the importance of these receptors in the integration of lipid metabolism and immune function, but also highlighting the need for a better understanding of the species, isoform, and cell-type specific effects of LXR activation.
ISSN:	1470-8752
DOI:	10.1042/bst20150112