Protein Kinase C-independent Activation of Protein Kinase D Is Involved in BMP-2-induced Activation of Stress Mitogen-activated Protein Kinases JNK and p38 and Osteoblastic Cell Differentiation

An important role for JNK* and p38 has recently been discovered in the differentiating effect of bone morphogenetic protein 2 (BMP-2) on osteoblastic cells. In this study, we investigated the molecular mechanism by which BMP-2 activates JNK and p38 in MC3T3-E1 osteoblastic cells. Activation of JNK a...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 279; no. 1; pp. 259 - 264
Main Authors:	Lemonnier, Jérome, Ghayor, Chafik, Guicheux, Jérome, Caverzasio, Joseph
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 02-01-2004 American Society for Biochemistry and Molecular Biology
Subjects:	3T3 Cells Animals Base Sequence Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - pharmacology Carbazoles - pharmacology Cell Differentiation Enzyme Activation Enzyme Inhibitors - pharmacology Indoles - pharmacology Kinetics Mice Mitogen-Activated Protein Kinases - metabolism Molecular Sequence Data Osteoblasts - cytology Osteoblasts - enzymology p38 Mitogen-Activated Protein Kinases Protein Kinase C - antagonists & inhibitors Protein Kinase C - genetics Protein Kinase C - metabolism RNA, Messenger - genetics Transforming Growth Factor alpha - pharmacology Transforming Growth Factor beta
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