DNMT3B PWWP mutations cause hypermethylation of heterochromatin

The correct establishment of DNA methylation patterns is vital for mammalian development and is achieved by the de novo DNA methyltransferases DNMT3A and DNMT3B. DNMT3B localises to H3K36me3 at actively transcribing gene bodies via its PWWP domain. It also functions at heterochromatin through an unk...

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Bibliographic Details

Published in:	EMBO reports Vol. 25; no. 3; pp. 1130 - 1155
Main Authors:	Taglini, Francesca, Kafetzopoulos, Ioannis, Rolls, Willow, Musialik, Kamila Irena, Lee, Heng Yang, Zhang, Yujie, Marenda, Mattia, Kerr, Lyndsay, Finan, Hannah, Rubio-Ramon, Cristina, Gautier, Philippe, Wapenaar, Hannah, Kumar, Dhananjay, Davidson-Smith, Hazel, Wills, Jimi, Murphy, Laura C, Wheeler, Ann, Wilson, Marcus D, Sproul, Duncan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12-03-2024
Subjects:	Biomedical and Life Sciences EMBO09 Life Sciences Epigenetics DNA Methylation Heterochromatin
Online Access:	Get full text
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