NMDA Receptor Gating of Information Flow through the Striatum In Vivo

A role of NMDA receptors in corticostriatal synaptic plasticity is widely acknowledged. However, the conditions that allow NMDA receptor activation in the striatum in vivo remain obscure. Here we show that NMDA receptors contribute to sustain the membrane potential of striatal medium spiny projectio...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 28; no. 50; pp. 13384 - 13389
Main Authors:	Pomata, Pablo E, Belluscio, Mariano A, Riquelme, Luis A, Murer, M. Gustavo
Format:	Journal Article
Language:	English
Published:	United States Soc Neuroscience 10-12-2008 Society for Neuroscience
Subjects:	Animals Brief Communications Corpus Striatum - physiology Ion Channel Gating - physiology Learning - physiology Male Membrane Potentials - physiology Microdialysis Neurons - metabolism Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism
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Summary:	A role of NMDA receptors in corticostriatal synaptic plasticity is widely acknowledged. However, the conditions that allow NMDA receptor activation in the striatum in vivo remain obscure. Here we show that NMDA receptors contribute to sustain the membrane potential of striatal medium spiny projection neurons close to threshold during spontaneous UP states in vivo. Moreover, we found that the blockade of striatal NMDA receptors reduces markedly the spontaneous firing of ensembles of medium spiny neurons during slow waves in urethane-anesthetized rats. We speculate that recurrent activation of NMDA receptors during UP states allows off-line information flow through the striatum and system level consolidation during habit formation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0270-6474 1529-2401 1529-2401
DOI:	10.1523/JNEUROSCI.4343-08.2008