Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata
Three new compounds ( - ), including a sesterterpenoid, aspterpenacid C ( ), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones ( - ), were isolated from the ethanol extract of the traditional Chinese medicinal plant Their structures were elucidated on the basis of th...
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Published in: | Planta medica Vol. 83; no. 17; p. 1368 |
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Main Authors: | , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Germany
01-11-2017
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Subjects: | |
Online Access: | Get more information |
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Summary: | Three new compounds (
-
), including a sesterterpenoid, aspterpenacid C (
), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones (
-
), were isolated from the ethanol extract of the traditional Chinese medicinal plant
Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structure of
was further confirmed by single-crystal X-ray diffraction analysis. Compounds
-
were tested for activities on the inhibition of nitric oxide production and HIV-1 replication
. Compound
exhibited moderate activity in inhibiting nitric oxide production (IC
= 16.1 µM) and HIV-1 replication (EC
= 1.35 µM). |
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ISSN: | 1439-0221 |
DOI: | 10.1055/s-0043-114736 |