Novel kinin B1 receptor agonists with improved pharmacological profiles

There is some evidence to suggest that inducible kinin B1 receptors (B1R) may play beneficial and protecting roles in cardiovascular-related pathologies such as hypertension, diabetes, and ischemic organ diseases. Peptide B1R agonists bearing optimized pharmacological features (high potency, selecti...

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Bibliographic Details
Published in:	Peptides (New York, N.Y. : 1980) Vol. 30; no. 4; pp. 788 - 795
Main Authors:	Côté, Jérôme, Savard, Martin, Bovenzi, Veronica, Bélanger, Simon, Morin, Josée, Neugebauer, Witold, Larouche, Annie, Dubuc, Céléna, Gobeil, Fernand
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-04-2009 Elsevier
Subjects:	Animals B1 receptor Binding, Competitive Biological and medical sciences Biological assays Blood Pressure - drug effects Cell Line Fundamental and applied biological sciences. Psychology Human Humans In Vitro Techniques Kinins Lipopolysaccharides - administration & dosage Male Peptides Peptides - chemistry Peptides - metabolism Peptides - pharmacology Protein Conformation Rabbits Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Bradykinin - agonists Vertebrates: endocrinology Human Kinins Peptides B1 receptor Biological assays Assay Agonist Kinin Biological receptor
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