Complementary and Alternative Medicine Strategies for Therapeutic Gut Microbiota Modulation in Inflammatory Bowel Disease and their Next-Generation Approaches

• Published in: Gastroenterology clinics of North America Vol. 46; no. 4; pp. 689 - 729
• Main Authors: Basson, Abigail R., Lam, Minh, Cominelli, Fabio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-12-2017
• Subjects: Animals; Caseins - therapeutic use; Complementary and alternative medicine; Complementary Therapies; Crohn disease; Diet; Dietary Supplements; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Gut microbiota; Humans; Inflammatory bowel disease; Inflammatory Bowel Diseases - therapy; Medical Marijuana - therapeutic use; Next-generation; Nutraceuticals; Peptide Fragments - therapeutic use; Phytochemicals - therapeutic use; Polysaccharides - therapeutic use; Prebiotics; Probiotics - therapeutic use; Psychophysiology; Ulcerative colitis; Inflammatory bowel disease; Gut microbiota; Crohn disease; Complementary and alternative medicine; Next-generation; Ulcerative colitis; Nutraceuticals
• ISSN: 0889-8553; 1558-1942
• DOI: 10.1016/j.gtc.2017.08.002

The human gut microbiome exerts a major impact on human health and disease, and therapeutic gut microbiota modulation is now a well-advocated strategy in the management of many diseases, including inflammatory bowel disease (IBD). Scientific and clinical evidence in support of complementary and alternative medicine, in targeting intestinal dysbiosis among patients with IBD, or other disorders, has increased dramatically over the past years. Delivery of “artificial” stool replacements for fecal microbiota transplantation (FMT) could provide an effective, safer alternative to that of human donor stool. Nevertheless, optimum timing of FMT administration in IBD remains unexplored, and future investigations are essential.