Liver fibrosis improvement in chronic hepatitis C after direct acting-antivirals is accompanied by reduced profibrogenic biomarkers–a role for MMP-9/TIMP-1

Disturbances in matrix metalloproteinases (MMPs) and corresponding tissue inhibitors (TIMPs) contribute to hepatitis C virus (HCV)-induced fibrosis. This study aimed to determine MMP-9/TIMP-1 levels in addition to MMP-2 and -9 activities; correlating with the improvement of liver fibrosis in patient...

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Bibliographic Details

Published in:	Digestive and liver disease Vol. 52; no. 10; pp. 1170 - 1177
Main Authors:	Medeiros, Thalia, Saraiva, Geórgia N, Moraes, Laiz A, Gomes, Aline C, Lacerda, Gilmar S, Leite, Paulo EC, Esberard, Eliane BC, Andrade, Thaís G, Xavier, Analúcia R, Quírico-Santos, Thereza, Rosário, Natalia F, Silva, Andrea A
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-10-2020
Subjects:	Chronic hepatitis C Direct-acting antivirals Fibrosis Matrix metalloproteinase Chronic hepatitis C Matrix metalloproteinase Fibrosis Direct-acting antivirals
Online Access:	Get full text
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