Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: Anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents
The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases. The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be us...
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| Published in: | Journal of ethnopharmacology Vol. 142; no. 3; pp. 845 - 850 |
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| Abstract | The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases.
The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be useful to treat gouty arthritis by countering hyperuricemia and inflammation.
L. trichocarpha ethanolic extract (LTE), ethyl acetate fraction from ethanolic extract (LTA) and isolated compounds were evaluated for urate-lowering activity and liver xanthine oxidase (XOD) inhibition in oxonate-induced hyperuricemic mice. Anti-inflammatory activity in monosodium urate crystal-induced paw oedema, an experimental model of gouty arthritis, was also investigated.
Crude ethanolic extract and its ethyl acetate fraction showed significant urate-lowering effects. LTE was also able to significantly inhibit liver xantine oxidase (XOD) activity in vivo at the dose of 250mg/kg. Luteolin, apigenin, lupeol, lychnopholide and eremantholide C showed the anti-hyperuricemic activities among tested compounds. Apigenin also showed XOD inhibitory activity in vivo. Luteolin, lychnopholide, lupeol and eremantholide C, in turn, did not shown significant inhibitory activity towards this enzyme, indicating that this mechanism is not likely to be involved in urate-lowering effects of those compounds. LTE, LTA, lupeol, β-sitosterol, lychnopholide, eremantholide, luteolin and apigenin were also found to inhibit monosodium urate crystals-induced paw oedema in mice.
Ethanolic extract of Lychnophora trichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possesses both anti-hiperuricemic and anti-inflammatory properties.
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| AbstractList | ETHNOPHARMACOLOGICAL RELEVANCEThe ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases.AIM OF THE STUDYThe present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be useful to treat gouty arthritis by countering hyperuricemia and inflammation.MATERIALS AND METHODSL. trichocarpha ethanolic extract (LTE), ethyl acetate fraction from ethanolic extract (LTA) and isolated compounds were evaluated for urate-lowering activity and liver xanthine oxidase (XOD) inhibition in oxonate-induced hyperuricemic mice. Anti-inflammatory activity in monosodium urate crystal-induced paw oedema, an experimental model of gouty arthritis, was also investigated.RESULTSCrude ethanolic extract and its ethyl acetate fraction showed significant urate-lowering effects. LTE was also able to significantly inhibit liver xantine oxidase (XOD) activity in vivo at the dose of 250mg/kg. Luteolin, apigenin, lupeol, lychnopholide and eremantholide C showed the anti-hyperuricemic activities among tested compounds. Apigenin also showed XOD inhibitory activity in vivo. Luteolin, lychnopholide, lupeol and eremantholide C, in turn, did not shown significant inhibitory activity towards this enzyme, indicating that this mechanism is not likely to be involved in urate-lowering effects of those compounds. LTE, LTA, lupeol, β-sitosterol, lychnopholide, eremantholide, luteolin and apigenin were also found to inhibit monosodium urate crystals-induced paw oedema in mice.CONCLUSIONSEthanolic extract of Lychnophora trichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possesses both anti-hiperuricemic and anti-inflammatory properties. The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases. The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be useful to treat gouty arthritis by countering hyperuricemia and inflammation. L. trichocarpha ethanolic extract (LTE), ethyl acetate fraction from ethanolic extract (LTA) and isolated compounds were evaluated for urate-lowering activity and liver xanthine oxidase (XOD) inhibition in oxonate-induced hyperuricemic mice. Anti-inflammatory activity in monosodium urate crystal-induced paw oedema, an experimental model of gouty arthritis, was also investigated. Crude ethanolic extract and its ethyl acetate fraction showed significant urate-lowering effects. LTE was also able to significantly inhibit liver xantine oxidase (XOD) activity in vivo at the dose of 250mg/kg. Luteolin, apigenin, lupeol, lychnopholide and eremantholide C showed the anti-hyperuricemic activities among tested compounds. Apigenin also showed XOD inhibitory activity in vivo. Luteolin, lychnopholide, lupeol and eremantholide C, in turn, did not shown significant inhibitory activity towards this enzyme, indicating that this mechanism is not likely to be involved in urate-lowering effects of those compounds. LTE, LTA, lupeol, β-sitosterol, lychnopholide, eremantholide, luteolin and apigenin were also found to inhibit monosodium urate crystals-induced paw oedema in mice. Ethanolic extract of Lychnophora trichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possesses both anti-hiperuricemic and anti-inflammatory properties. The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases. The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bioactive compounds could be useful to treat gouty arthritis by countering hyperuricemia and inflammation. L. trichocarpha ethanolic extract (LTE), ethyl acetate fraction from ethanolic extract (LTA) and isolated compounds were evaluated for urate-lowering activity and liver xanthine oxidase (XOD) inhibition in oxonate-induced hyperuricemic mice. Anti-inflammatory activity in monosodium urate crystal-induced paw oedema, an experimental model of gouty arthritis, was also investigated. Crude ethanolic extract and its ethyl acetate fraction showed significant urate-lowering effects. LTE was also able to significantly inhibit liver xantine oxidase (XOD) activity in vivo at the dose of 250mg/kg. Luteolin, apigenin, lupeol, lychnopholide and eremantholide C showed the anti-hyperuricemic activities among tested compounds. Apigenin also showed XOD inhibitory activity in vivo. Luteolin, lychnopholide, lupeol and eremantholide C, in turn, did not shown significant inhibitory activity towards this enzyme, indicating that this mechanism is not likely to be involved in urate-lowering effects of those compounds. LTE, LTA, lupeol, β-sitosterol, lychnopholide, eremantholide, luteolin and apigenin were also found to inhibit monosodium urate crystals-induced paw oedema in mice. Ethanolic extract of Lychnophora trichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possesses both anti-hiperuricemic and anti-inflammatory properties. [Display omitted] |
| Author | Pereira de Resende, Michelle Luciane de Paula, Carmen Aparecida Saúde-Guimarães, Dênia Antunes Grabe-Guimarães, Andrea de Souza Filho, José Dias de Souza, Maíra Ribeiro |
| Author_xml | – sequence: 1 givenname: Maíra Ribeiro surname: de Souza fullname: de Souza, Maíra Ribeiro organization: Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil – sequence: 2 givenname: Carmen Aparecida surname: de Paula fullname: de Paula, Carmen Aparecida organization: Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil – sequence: 3 givenname: Michelle Luciane surname: Pereira de Resende fullname: Pereira de Resende, Michelle Luciane organization: Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil – sequence: 4 givenname: Andrea surname: Grabe-Guimarães fullname: Grabe-Guimarães, Andrea organization: Laboratório de Farmacologia Experimental, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil – sequence: 5 givenname: José Dias surname: de Souza Filho fullname: de Souza Filho, José Dias organization: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Brazil – sequence: 6 givenname: Dênia Antunes surname: Saúde-Guimarães fullname: Saúde-Guimarães, Dênia Antunes email: saude@ef.ufop.br, saudeguima@gmail.com organization: Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22732730$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1211/0022357011777909 10.1016/S0014-2999(02)02192-1 10.1016/j.fct.2011.04.029 10.1016/0003-2697(76)90527-3 10.1248/bpb.24.470 10.1016/j.jep.2006.02.011 10.1248/bpb.30.1551 10.1007/s11357-997-0012-2 10.1254/jphs.CRJ04003X 10.1016/0024-3205(90)90507-N 10.1016/j.jep.2008.02.031 10.1007/s10753-010-9222-3 10.1016/j.cbi.2006.09.011 10.1002/jccs.200400094 10.1016/j.jep.2007.11.006 10.1016/S0006-291X(02)00442-4 10.1016/j.berh.2004.01.001 10.1016/j.rdc.2006.03.001 10.1002/(SICI)1099-1573(199606)10:4<292::AID-PTR834>3.0.CO;2-O 10.3923/pjbs.2008.1779.1784 10.1016/S0968-0896(99)00195-9 10.2174/092986708784911579 10.3164/jcbn.09-15 10.1016/j.jep.2004.03.037 10.1016/j.cbi.2008.07.003 10.1136/ard.2010.136218 10.2174/138955709787001712 10.1038/sj.onc.1207641 |
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| Copyright | 2012 Elsevier Ireland Ltd Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
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| Keywords | Lychnophora trichocarpha Xanthine oxidase Hyperuricemia Sesquiterpene lactones Flavones Gout |
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| References | Gomes, Fernandes, Lima, Mira, Corvo (bib10) 2008; 1 Saleem, Afaq, Adhami, Mukhtar (bib30) 2004; 23 Mo, Zhou, Lv, Hu, Zhang, Kong (bib22) 2007; 30 Sabina, Nagar, Rasool (bib29) 2011; 34 Dubchak, Falasca (bib7) 2010; 3 Rüngeler, Castro, Mora, Goren, Vichewski, Pahl, Merfort, Schmidt (bib27) 1999; 7 Huang, Wang, Zhu, Chen, Zhu (bib15) 2011; 49 Ahmad, Farman, Najmi, Mian, Hasan (bib1) 2008; 117 Sabina, Chandal, Rasool (bib28) 2008; 11 Rasool, Varalakshmi (bib26) 2006; 164 Zhu, Wang, Kong, Yang, Zhang (bib34) 2004; 93 Liu, Chen, Shang, Jiao, Huang (bib19) 2008; 176 Haidari, Rashidi, Keshavarz (bib12) 2008; 11 Dalbeth, So (bib5) 2010; 69 Lin, Chen, Chen, Liang, Lin (bib17) 2002; 294 Lioté, Ea (bib18) 2006; 32 Haidari, Keshavarz, Rashidi, Shahi (bib13) 2009; 45 Van-Hoorn, Nijveldt, Van-Leeuwen, Hofman, M'rabet, De-Bont, Van-Norren (bib32) 2002; 451 Kim, Son, Chang, Kang (bib16) 2004; 245 Bradford (bib2) 1976; 72 Cerqueira, Souza, Júnior, Peixoto (bib3) 1987; 39 Chung, Baek, Song, Kim, Huh, Shim, Kim, Lee (bib4) 1997; 20 Deng, Song, Wang (bib6) 2004; 51 López-Lázaro (bib20) 2009; 9 Vázquez-Mellado, Hernández, Burgos-Vargas (bib33) 2004; 18 Ferraz-Filha, Vitolo, Fietto, Lombardi, Saúde-Guimarães (bib9) 2006; 107 Oliveira, Saúde, Perry, Duarte, Raslan, Boaventura, Chiari (bib24) 1996; 10 Fernández, De Las Heras, Garcia, Sáenz, Villar (bib8) 2001; 53 Özgen, Mavi, Terzi, Kazaz, Asçi, Kaya, Seçen (bib25) 2011; 5 Guzzo, Saúde-Guimarães, Silva, Lombardi, Guimarães, Grabe-Guimarães (bib11) 2008; 116 Hall, Scoville, Reynolds, Simlot, Duncan (bib14) 1990; 46 Mattace Raso, Meli, Di Carlo, Pacilio, Di Carlo (bib21) 2001; 68 Navarro, De Las Heras, Villar (bib23) 2001; 24 Saúde, Raslan, Souza Filho, Oliveira (bib31) 1998 Rasool (10.1016/j.jep.2012.06.012_bib26) 2006; 164 Rüngeler (10.1016/j.jep.2012.06.012_bib27) 1999; 7 Ferraz-Filha (10.1016/j.jep.2012.06.012_bib9) 2006; 107 Chung (10.1016/j.jep.2012.06.012_bib4) 1997; 20 Liu (10.1016/j.jep.2012.06.012_bib19) 2008; 176 Saúde (10.1016/j.jep.2012.06.012_bib31) 1998 Lioté (10.1016/j.jep.2012.06.012_bib18) 2006; 32 Deng (10.1016/j.jep.2012.06.012_bib6) 2004; 51 Navarro (10.1016/j.jep.2012.06.012_bib23) 2001; 24 Saleem (10.1016/j.jep.2012.06.012_bib30) 2004; 23 Kim (10.1016/j.jep.2012.06.012_bib16) 2004; 245 Hall (10.1016/j.jep.2012.06.012_bib14) 1990; 46 Guzzo (10.1016/j.jep.2012.06.012_bib11) 2008; 116 Zhu (10.1016/j.jep.2012.06.012_bib34) 2004; 93 Fernández (10.1016/j.jep.2012.06.012_bib8) 2001; 53 Bradford (10.1016/j.jep.2012.06.012_bib2) 1976; 72 Haidari (10.1016/j.jep.2012.06.012_bib13) 2009; 45 Özgen (10.1016/j.jep.2012.06.012_bib25) 2011; 5 Mo (10.1016/j.jep.2012.06.012_bib22) 2007; 30 Vázquez-Mellado (10.1016/j.jep.2012.06.012_bib33) 2004; 18 Sabina (10.1016/j.jep.2012.06.012_bib29) 2011; 34 Sabina (10.1016/j.jep.2012.06.012_bib28) 2008; 11 Lin (10.1016/j.jep.2012.06.012_bib17) 2002; 294 Gomes (10.1016/j.jep.2012.06.012_bib10) 2008; 1 Oliveira (10.1016/j.jep.2012.06.012_bib24) 1996; 10 Haidari (10.1016/j.jep.2012.06.012_bib12) 2008; 11 Cerqueira (10.1016/j.jep.2012.06.012_bib3) 1987; 39 Huang (10.1016/j.jep.2012.06.012_bib15) 2011; 49 Mattace Raso (10.1016/j.jep.2012.06.012_bib21) 2001; 68 Ahmad (10.1016/j.jep.2012.06.012_bib1) 2008; 117 Dubchak (10.1016/j.jep.2012.06.012_bib7) 2010; 3 López-Lázaro (10.1016/j.jep.2012.06.012_bib20) 2009; 9 Dalbeth (10.1016/j.jep.2012.06.012_bib5) 2010; 69 Van-Hoorn (10.1016/j.jep.2012.06.012_bib32) 2002; 451 |
| References_xml | – volume: 30 start-page: 1551 year: 2007 end-page: 1556 ident: bib22 article-title: Hypouricemic action of selected flavonoids in mice: structure–activity relationships publication-title: Biological & Pharmaceutical Bulletin contributor: fullname: Kong – volume: 46 start-page: 1923 year: 1990 end-page: 1927 ident: bib14 article-title: Substituted cyclic imides as potencial anti-gout agents publication-title: Life Sciences contributor: fullname: Duncan – volume: 34 start-page: 184 year: 2011 end-page: 192 ident: bib29 article-title: A role of piperine on monosodium urate crystal-induced inflammation—an experimental model of gouty arthritis publication-title: Inflammation contributor: fullname: Rasool – volume: 23 start-page: 5203 year: 2004 end-page: 5214 ident: bib30 article-title: Lupeol modulates NF- publication-title: Oncogene contributor: fullname: Mukhtar – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: bib2 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding publication-title: Analytical Biochemistry contributor: fullname: Bradford – volume: 5 start-page: 12 year: 2011 end-page: 21 ident: bib25 article-title: Relationship between chemical structure and antioxidant activity of luteolin and its glycosides isolated from publication-title: Records of Natural Products contributor: fullname: Seçen – volume: 10 start-page: 292 year: 1996 end-page: 295 ident: bib24 article-title: Trypanocidal sesquiterpenes from Lychnophora species publication-title: Phytotherapy Research contributor: fullname: Chiari – volume: 93 start-page: 133 year: 2004 end-page: 140 ident: bib34 article-title: Effects of publication-title: Journal of Ethnopharmacology contributor: fullname: Zhang – volume: 176 start-page: 137 year: 2008 end-page: 142 ident: bib19 article-title: Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats publication-title: Chemico-Biological Interactions contributor: fullname: Huang – volume: 18 start-page: 111 year: 2004 end-page: 124 ident: bib33 article-title: Primary prevention in rheumatology: the importance of hyperuricemia publication-title: Best Practice & Research Clinical Rheumatology contributor: fullname: Burgos-Vargas – volume: 9 start-page: 31 year: 2009 end-page: 59 ident: bib20 article-title: Distribution and biological activities of the flavonoid luteolin publication-title: Mini Reviews in Medicinal Chemistry contributor: fullname: López-Lázaro – volume: 45 start-page: 285 year: 2009 end-page: 291 ident: bib13 article-title: Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity publication-title: Journal of Clinical and Biochemical Nutrition contributor: fullname: Shahi – volume: 164 start-page: 174 year: 2006 end-page: 180 ident: bib26 article-title: Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study publication-title: Chemico-biological interactions contributor: fullname: Varalakshmi – volume: 51 start-page: 629 year: 2004 end-page: 636 ident: bib6 article-title: Chemical components of publication-title: Journal of the Chinese Chemical Society contributor: fullname: Wang – volume: 24 start-page: 470 year: 2001 end-page: 473 ident: bib23 article-title: Anti-inflammatory and immunomodulating properties of a sterol fraction from Sideritis foetens Clem publication-title: Biological Pharmaceutical Bulletim contributor: fullname: Villar – start-page: 90 year: 1998 end-page: 91 ident: bib31 article-title: Constituents from the aerial parts of publication-title: Fitoterapia LXIX contributor: fullname: Oliveira – volume: 107 start-page: 79 year: 2006 end-page: 82 ident: bib9 article-title: Xanthine oxidase inibitory activity of publication-title: Journal of Ethnopharmacology contributor: fullname: Saúde-Guimarães – volume: 49 start-page: 1943 year: 2011 end-page: 1947 ident: bib15 article-title: Effects of Genistein, Apigenin, Quercetin, Rutin and Astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice publication-title: Food and Chemical Toxicology contributor: fullname: Zhu – volume: 3 start-page: 145 year: 2010 end-page: 166 ident: bib7 article-title: New and improved strategies for the treatment of gout publication-title: International Journal of Nephrology and Renovascular Disease contributor: fullname: Falasca – volume: 117 start-page: 478 year: 2008 end-page: 482 ident: bib1 article-title: Pharmacological basis for use of publication-title: Journal of Ethnopharmacology contributor: fullname: Hasan – volume: 32 start-page: 295 year: 2006 end-page: 311 ident: bib18 article-title: Gout: update on some pathogenic and clinical aspects publication-title: Rheumatic Diseases Clinic of North America contributor: fullname: Ea – volume: 11 start-page: 46 year: 2008 end-page: 55 ident: bib28 article-title: Inhibition of monosodium urate crystal-induced inflammation by withaferin A publication-title: Journal of Pharmacy & Pharmaceutical Sciences contributor: fullname: Rasool – volume: 11 start-page: 1779 year: 2008 end-page: 1784 ident: bib12 article-title: Effects of onion on serum uric acid levels and hepatic xanthine dehidrogenase/xanthine oxidase activities in hyperuricemic rats publication-title: Pakistan Journal of Biological Sciences contributor: fullname: Keshavarz – volume: 7 start-page: 23 year: 1999 end-page: 43 ident: bib27 article-title: Inhibition of transcription factor NF- publication-title: Bioorganic & Medicinal Chemistry contributor: fullname: Schmidt – volume: 1 start-page: 1586 year: 2008 end-page: 1605 ident: bib10 article-title: Molecular mechanisms of anti-inflammatory activity mediated by flavonoids publication-title: Current Medicinal Chemistry contributor: fullname: Corvo – volume: 53 start-page: 1533 year: 2001 end-page: 1539 ident: bib8 article-title: New insights into the mechanism of action of the anti-inflammatory triterpene lupeol publication-title: Journal of Pharmacy and Pharmacology contributor: fullname: Villar – volume: 294 start-page: 167 year: 2002 end-page: 172 ident: bib17 article-title: Molecular modeling of flavonoids that inhibit xanthine oxidase publication-title: Biochemical and Biophysical Research Communications contributor: fullname: Lin – volume: 69 start-page: 1738 year: 2010 end-page: 1743 ident: bib5 article-title: Hyperuricaemia and gout: state of the art and future perspectives publication-title: Annals of the Rheumatic Diseases contributor: fullname: So – volume: 245 start-page: 229 year: 2004 end-page: 245 ident: bib16 article-title: Anti-inflammatory plant flavonoids and cellular action mechanisms publication-title: Journal of Pharmacological Sciences contributor: fullname: Kang – volume: 39 start-page: 551 year: 1987 end-page: 553 ident: bib3 article-title: Ação analgésica do extrato bruto aquoso liofilizado do caule e folhas da publication-title: Ciência e Cultura contributor: fullname: Peixoto – volume: 451 start-page: 111 year: 2002 end-page: 118 ident: bib32 article-title: Accurate prediction of xanthine oxidase inhibition based on thestructure of flavonoids publication-title: European Journal of Pharmacology contributor: fullname: Van-Norren – volume: 116 start-page: 120 year: 2008 end-page: 124 ident: bib11 article-title: Antinociceptive and antiinflammatory activities of ethanolic extracts of Lychnophora species publication-title: Journal of Ethnopharmacology contributor: fullname: Grabe-Guimarães – volume: 20 start-page: 127 year: 1997 end-page: 140 ident: bib4 article-title: Xanthine dehydrogenase/xanthine oxidase and oxidative stress publication-title: Age contributor: fullname: Lee – volume: 68 start-page: 31 year: 2001 ident: bib21 article-title: Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1 publication-title: Life Sciences contributor: fullname: Di Carlo – volume: 53 start-page: 1533 year: 2001 ident: 10.1016/j.jep.2012.06.012_bib8 article-title: New insights into the mechanism of action of the anti-inflammatory triterpene lupeol publication-title: Journal of Pharmacy and Pharmacology doi: 10.1211/0022357011777909 contributor: fullname: Fernández – volume: 11 start-page: 46 year: 2008 ident: 10.1016/j.jep.2012.06.012_bib28 article-title: Inhibition of monosodium urate crystal-induced inflammation by withaferin A publication-title: Journal of Pharmacy & Pharmaceutical Sciences contributor: fullname: Sabina – volume: 451 start-page: 111 year: 2002 ident: 10.1016/j.jep.2012.06.012_bib32 article-title: Accurate prediction of xanthine oxidase inhibition based on thestructure of flavonoids publication-title: European Journal of Pharmacology doi: 10.1016/S0014-2999(02)02192-1 contributor: fullname: Van-Hoorn – volume: 49 start-page: 1943 year: 2011 ident: 10.1016/j.jep.2012.06.012_bib15 article-title: Effects of Genistein, Apigenin, Quercetin, Rutin and Astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2011.04.029 contributor: fullname: Huang – volume: 72 start-page: 248 year: 1976 ident: 10.1016/j.jep.2012.06.012_bib2 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding publication-title: Analytical Biochemistry doi: 10.1016/0003-2697(76)90527-3 contributor: fullname: Bradford – volume: 39 start-page: 551 year: 1987 ident: 10.1016/j.jep.2012.06.012_bib3 article-title: Ação analgésica do extrato bruto aquoso liofilizado do caule e folhas da Lychnophora ericoides Mart. (arnica) publication-title: Ciência e Cultura contributor: fullname: Cerqueira – volume: 24 start-page: 470 year: 2001 ident: 10.1016/j.jep.2012.06.012_bib23 article-title: Anti-inflammatory and immunomodulating properties of a sterol fraction from Sideritis foetens Clem publication-title: Biological Pharmaceutical Bulletim doi: 10.1248/bpb.24.470 contributor: fullname: Navarro – volume: 107 start-page: 79 year: 2006 ident: 10.1016/j.jep.2012.06.012_bib9 article-title: Xanthine oxidase inibitory activity of Lychnophora species from Brazil (“Arnica”) publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2006.02.011 contributor: fullname: Ferraz-Filha – volume: 30 start-page: 1551 year: 2007 ident: 10.1016/j.jep.2012.06.012_bib22 article-title: Hypouricemic action of selected flavonoids in mice: structure–activity relationships publication-title: Biological & Pharmaceutical Bulletin doi: 10.1248/bpb.30.1551 contributor: fullname: Mo – volume: 20 start-page: 127 year: 1997 ident: 10.1016/j.jep.2012.06.012_bib4 article-title: Xanthine dehydrogenase/xanthine oxidase and oxidative stress publication-title: Age doi: 10.1007/s11357-997-0012-2 contributor: fullname: Chung – start-page: 90 year: 1998 ident: 10.1016/j.jep.2012.06.012_bib31 article-title: Constituents from the aerial parts of Lychnophora trichocarpa publication-title: Fitoterapia LXIX contributor: fullname: Saúde – volume: 245 start-page: 229 year: 2004 ident: 10.1016/j.jep.2012.06.012_bib16 article-title: Anti-inflammatory plant flavonoids and cellular action mechanisms publication-title: Journal of Pharmacological Sciences doi: 10.1254/jphs.CRJ04003X contributor: fullname: Kim – volume: 46 start-page: 1923 year: 1990 ident: 10.1016/j.jep.2012.06.012_bib14 article-title: Substituted cyclic imides as potencial anti-gout agents publication-title: Life Sciences doi: 10.1016/0024-3205(90)90507-N contributor: fullname: Hall – volume: 117 start-page: 478 year: 2008 ident: 10.1016/j.jep.2012.06.012_bib1 article-title: Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2008.02.031 contributor: fullname: Ahmad – volume: 34 start-page: 184 year: 2011 ident: 10.1016/j.jep.2012.06.012_bib29 article-title: A role of piperine on monosodium urate crystal-induced inflammation—an experimental model of gouty arthritis publication-title: Inflammation doi: 10.1007/s10753-010-9222-3 contributor: fullname: Sabina – volume: 164 start-page: 174 year: 2006 ident: 10.1016/j.jep.2012.06.012_bib26 article-title: Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study publication-title: Chemico-biological interactions doi: 10.1016/j.cbi.2006.09.011 contributor: fullname: Rasool – volume: 51 start-page: 629 year: 2004 ident: 10.1016/j.jep.2012.06.012_bib6 article-title: Chemical components of Seriphidium santolium Poljak publication-title: Journal of the Chinese Chemical Society doi: 10.1002/jccs.200400094 contributor: fullname: Deng – volume: 116 start-page: 120 year: 2008 ident: 10.1016/j.jep.2012.06.012_bib11 article-title: Antinociceptive and antiinflammatory activities of ethanolic extracts of Lychnophora species publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2007.11.006 contributor: fullname: Guzzo – volume: 294 start-page: 167 year: 2002 ident: 10.1016/j.jep.2012.06.012_bib17 article-title: Molecular modeling of flavonoids that inhibit xanthine oxidase publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/S0006-291X(02)00442-4 contributor: fullname: Lin – volume: 18 start-page: 111 year: 2004 ident: 10.1016/j.jep.2012.06.012_bib33 article-title: Primary prevention in rheumatology: the importance of hyperuricemia publication-title: Best Practice & Research Clinical Rheumatology doi: 10.1016/j.berh.2004.01.001 contributor: fullname: Vázquez-Mellado – volume: 32 start-page: 295 year: 2006 ident: 10.1016/j.jep.2012.06.012_bib18 article-title: Gout: update on some pathogenic and clinical aspects publication-title: Rheumatic Diseases Clinic of North America doi: 10.1016/j.rdc.2006.03.001 contributor: fullname: Lioté – volume: 10 start-page: 292 year: 1996 ident: 10.1016/j.jep.2012.06.012_bib24 article-title: Trypanocidal sesquiterpenes from Lychnophora species publication-title: Phytotherapy Research doi: 10.1002/(SICI)1099-1573(199606)10:4<292::AID-PTR834>3.0.CO;2-O contributor: fullname: Oliveira – volume: 5 start-page: 12 year: 2011 ident: 10.1016/j.jep.2012.06.012_bib25 article-title: Relationship between chemical structure and antioxidant activity of luteolin and its glycosides isolated from Thymus sipyleus subsp. sipyleus var. sipyleus publication-title: Records of Natural Products contributor: fullname: Özgen – volume: 3 start-page: 145 year: 2010 ident: 10.1016/j.jep.2012.06.012_bib7 article-title: New and improved strategies for the treatment of gout publication-title: International Journal of Nephrology and Renovascular Disease contributor: fullname: Dubchak – volume: 11 start-page: 1779 year: 2008 ident: 10.1016/j.jep.2012.06.012_bib12 article-title: Effects of onion on serum uric acid levels and hepatic xanthine dehidrogenase/xanthine oxidase activities in hyperuricemic rats publication-title: Pakistan Journal of Biological Sciences doi: 10.3923/pjbs.2008.1779.1784 contributor: fullname: Haidari – volume: 7 start-page: 23 year: 1999 ident: 10.1016/j.jep.2012.06.012_bib27 article-title: Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action publication-title: Bioorganic & Medicinal Chemistry doi: 10.1016/S0968-0896(99)00195-9 contributor: fullname: Rüngeler – volume: 1 start-page: 1586 year: 2008 ident: 10.1016/j.jep.2012.06.012_bib10 article-title: Molecular mechanisms of anti-inflammatory activity mediated by flavonoids publication-title: Current Medicinal Chemistry doi: 10.2174/092986708784911579 contributor: fullname: Gomes – volume: 45 start-page: 285 year: 2009 ident: 10.1016/j.jep.2012.06.012_bib13 article-title: Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity publication-title: Journal of Clinical and Biochemical Nutrition doi: 10.3164/jcbn.09-15 contributor: fullname: Haidari – volume: 93 start-page: 133 year: 2004 ident: 10.1016/j.jep.2012.06.012_bib34 article-title: Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2004.03.037 contributor: fullname: Zhu – volume: 68 start-page: 31 issue: 921 year: 2001 ident: 10.1016/j.jep.2012.06.012_bib21 article-title: Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1 publication-title: Life Sciences contributor: fullname: Mattace Raso – volume: 176 start-page: 137 year: 2008 ident: 10.1016/j.jep.2012.06.012_bib19 article-title: Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats publication-title: Chemico-Biological Interactions doi: 10.1016/j.cbi.2008.07.003 contributor: fullname: Liu – volume: 69 start-page: 1738 year: 2010 ident: 10.1016/j.jep.2012.06.012_bib5 article-title: Hyperuricaemia and gout: state of the art and future perspectives publication-title: Annals of the Rheumatic Diseases doi: 10.1136/ard.2010.136218 contributor: fullname: Dalbeth – volume: 9 start-page: 31 year: 2009 ident: 10.1016/j.jep.2012.06.012_bib20 article-title: Distribution and biological activities of the flavonoid luteolin publication-title: Mini Reviews in Medicinal Chemistry doi: 10.2174/138955709787001712 contributor: fullname: López-Lázaro – volume: 23 start-page: 5203 year: 2004 ident: 10.1016/j.jep.2012.06.012_bib30 article-title: Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice publication-title: Oncogene doi: 10.1038/sj.onc.1207641 contributor: fullname: Saleem |
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| Snippet | The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases.
The present study... ETHNOPHARMACOLOGICAL RELEVANCEThe ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and... |
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| SubjectTerms | Acetates - chemistry Animals Anti-Inflammatory Agents - analysis Anti-Inflammatory Agents - therapeutic use Arthritis, Gouty - drug therapy Asteraceae Ethanol - chemistry Flavones Flavonoids - analysis Flavonoids - therapeutic use Gout Hyperuricemia Hyperuricemia - chemically induced Hyperuricemia - drug therapy Hyperuricemia - metabolism Inflammation - chemically induced Inflammation - drug therapy Liver - drug effects Liver - enzymology Lychnophora trichocarpha Male Mice Oxonic Acid Phytotherapy Plant Components, Aerial - chemistry Plant Extracts - chemistry Plant Extracts - therapeutic use Sesquiterpene lactones Solvents - chemistry Uric Acid - blood Xanthine oxidase Xanthine Oxidase - metabolism |
| Title | Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: Anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents |
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